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Hepatic encephalopathy : novel insights into classification, pathophysiology and therapy
(Elsevier, 2020-10-21)
Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric abnormalities, from subclinical changes (mild ...
Progressive resistance training prevents loss of muscle mass and strength in bile duct‐ligated rats
(Wiley, 2018-11-05)
BACKGROUND: Loss of muscle mass and strength is common in cirrhosis and increases
the risk of hyperammonaemia and hepatic encephalopathy. Resistance training
optimizes muscle mass and strength in several ...
Impact of uric acid on liver injury and intestinal permeability following resuscitated hemorrhagic shock in rats
(Lippincott, Williams & Wilkins, 2020-07-06)
BACKGROUND
Multiorgan failure is a consequence of severe ischemia-reperfusion injury after traumatic hemorrhagic shock (HS), a major cause of mortality in trauma patients. Circulating uric acid (UA), released from cell ...
Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure
(Wiley, 2017-01-19)
Background/Aim
Acetaminophen (APAP)-induced Acute Liver Failure (ALF) is associated with significant mortality. Traditional prognostic scores lack sensitivity. Hypothesis: Serum Liver-type Fatty Acid Binding Protein (FABP1) ...
Nutritional strategies to manage malnutrition and sarcopenia following liver transplantation : a narrative review
(MDPI, 2023-02-10)
Persisting or newly developed malnutrition and sarcopenia after liver transplant (LT) are correlated with adverse health outcomes. This narrative review aims to examine the literature regarding nutrition strategies to ...
Astrocyte glutamine synthetase : pivotal in health and disease
(Portland Press, 2013)
The multifunctional properties of astrocytes signify their importance in brain physiology and neurological function. In addition to defining the brain architecture, astrocytes are primary elements of brain ion, pH and ...
Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats
(Wiley, 2013-11-25)
Background & Aims The pathogenesis of hepatic encephalopathy (HE) is multifactorial and often associated with the
development of brain oedema. In addition to ammonia playing a central role, systemic oxidative stress is ...
Elevated cerebral lactate : implications in the pathogenesis of hepatic encephalopathy
(Springer, 2014-06-11)
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver
failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation,
but ...
Judging the value of ammonia measurement on lactulose dosing : apples and oranges?
(University of Toronto Press, 2021-02-24)