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  • Assessment of the sensitivity of detecting drug-induced QTc changes using subject-specific rate correction 

    Cassani González, Raymundo; Engels, Elien B.; Dubé, Bruno; Nadeau, Reginald; Vinet, Alain; Leblanc, Aime Robert; Sturmer, Marcio; Becker, Giuliano; Kus, Térésa; Jacquemet, Vincent (Elsevier, 2012)
    Aims To quantify the sensitivity of QT heart-rate correction methods for detecting drug-induced QTc changes in thorough QT studies. Methods Twenty-four-hour Holter ECGs were analyzed in 66 normal subjects during placebo and moxifloxacin delivery ...

  • QT interval measurement and correction in patients with atrial flutter : a pilot study 

    Jacquemet, Vincent; Cassani González, Raymundo; Sturmer, Marcio; Dubé, Bruno; Sharestan, Jean; Vinet, Alain; Mahiddine, Omar; Leblanc, Aime Robert; Becker, Giuliano; Kus, Térésa; Nadeau, Reginald (Elsevier, 2014)
    Background and Purpose Measurement of QT intervals during atrial flutter (AFL) is relevant to monitor the safety of drug delivery. Our aim is to compare QT and QTc intervals in AFL patients before and after catheter ablation in order to validate QT ...