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  • Autophagy drives fibroblast senescence through MTORC2 regulation 

    Autophagy, senescence and myofibroblast differentiation
    Bernard, Monique; Yang, Bing; Migneault, Francis; Turgeon, Julie; Dieudé, Mélanie; Olivier, Marc-Alexandre; Cardin, Guillaume B.; El-Diwany, Mostafa; Underwood, Katy; Rodier, Francis; Hébert, Marie-Josée (Taylor & Francis, 2020-01-13)
    Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means of responding to long-term cellular stress, has also been linked to myofibroblast differentiation and fibrosis. Here, ...