Browsing Faculté de médecine by Author "Orthwein, Alexandre"
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Active nuclear import and cytoplasmic retention of activation-induced deaminase
Patenaude, Anne-Marie; Orthwein, Alexandre; Hu, Yi; Campo, Vanina A.; Kavli, Bodil; Buschiazzo, Alejandro; Di Noia, Javier Marcelo (2009)The enzyme activation-induced deaminase (AID) triggers antibody diversification in B cells by catalyzing deamination and consequently mutation of immunoglobulin genes. To minimize off-target deamination, AID is restrained by several regulatory mechanisms ... -
Importance of the HSP90 molecular chaperoning pathway for antibody diversification by determining AID stability
Orthwein, Alexandre (2012-05-03)La protéine AID (déaminase induite par l’activation) joue un rôle central dans la réponse immunitaire adaptative. En désaminant des désoxycytidines en désoxyuridines au niveau des gènes immunoglobulines, elle initie l’hypermutation somatique (SHM), ...