Browsing Faculté de médecine by Author "Bachais, Meriem"
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PD-1 endocytosis unleashes the cytolytic potential of check-point blockade in tumor immunity
Ben Saad, Elham; Oroya, Andres; Anto, Nikhil Ponnoor; Bachais, Meriem; Rudd, Christopher E. (2024)PD-1 immune checkpoint blockade (ICB) is now a promising first-line treatment for many cancers. While the steric blockade of PD-1 binding to its ligand plays a role, the role of internalisation in promoting the efficacy of ICB has not been explored. ...