Browsing Faculté de médecine by Affiliation "Université de Montréal. Faculté de médecine. Département de pharmacologie et physiologie"
Now showing items 1-20 of 56
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Amino acids, ammonia, and hepatic encephalopathy
(Elsevier, 2022-04-30)Hepatic encephalopathy (HE) is a decline in brain function arising due to liver insufficiency. The liver's diminished capacity to clear ammonia, and the subsequent accumulation of it, is highly implicated in pathogenesis of HE. Ammonia is endogenously ... -
Analysis of electrocardiograms during atrial fibrillation
(Institute of electrical and electronics engineers, 2006-11-30)The research discussed in this article is motivated by the search for an optimal classification of the different types of atrial fibrillation (AF) on the basis of recorded atrial signals. This would facilitate the selection of an optimal therapy. This ... -
Article processing charge hyperinflation and price insensitivity : an open access sequel to the serials crisis
(LIBER, 2019)Open access publishing has frequently been proposed as a solution to the serials crisis, which involved unsustainable budgetary pressures on libraries due to hyperinflation of subscription costs. The majority of open access articles are published in ... -
Assessment of the sensitivity of detecting drug-induced QTc changes using subject-specific rate correction
(Elsevier, 2012)Aims To quantify the sensitivity of QT heart-rate correction methods for detecting drug-induced QTc changes in thorough QT studies. Methods Twenty-four-hour Holter ECGs were analyzed in 66 normal subjects during placebo and moxifloxacin delivery ... -
A CACNA1C variant associated with cardiac arrhythmias provides mechanistic insights in the calmodulation of L-type Ca2+ channels
(Elsevier, 2022)We recently reported the identification of a de novo single nucleotide variant in exon 9 of CACNA1C associated with prolonged repolarization interval. Recombinant expression of the glycine to arginine variant at position 419 produced a gain in the ... -
Cancellation of ventricular activity in the ECG : evaluation of novel and existing methods
(Institute of electrical and electronics engineers, 2007-02-20)Due to the much higher amplitude of the electrical activity of the ventricles in the surface electrocardiogram (ECG), its cancellation is crucial for the analysis and characterization of atrial fibrillation. In this paper, two different methods are ... -
clc is co-expressed with clf or cntfr in developing mouse muscles
(2005)BACKGROUND:The ciliary neurotrophic factor (CNTF) receptor is composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor, associated with a non-signalling CNTF binding receptor a component (CNTFR). This tripartite ... -
Distinct cognitive and discriminative stimulus effects of ketamine enantiomers in rats
(Elsevier, 2020-08-03)Although (S)-ketamine was approved for use in treatment-resistant depression in 2019, new preclinical findings suggest that (R)-ketamine might produce better efficacy and tolerability relative to (S)-ketamine. Here we evaluated the effects of (R)-, ... -
Dopaminergic mechanisms underlying the expression of antipsychotic-induced dopamine supersensitivity in rats
(Elsevier, 2021-08-05)Antipsychotic treatment can produce a dopamine-supersensitive state, potentiating the response to dopamine receptor stimulation. In both schizophrenia patients and rats, this is linked to tolerance to ongoing antipsychotic treatment. In rodents, dopamine ... -
Efects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats
(Springer, 2022-03-02)Rationale Ketamine and psilocybin belong to the rapid-acting antidepressants but they also produce psychotomimetic efects including timing distortion. It is currently debatable whether these are essential for their therapeutic actions. As depressed patients ... -
The effect of tissue geometry on the activation recovery interval of atrial myocytes
(Elsevier, 2008-08-13)The propagation of electric activity inside a realistically-shaped, thick-walled model of the atria was studied. The membrane kinetics was based on the formulations of Courtemanche, Ramirez and Nattel. In spite of the assumed uniformity of all ... -
Effects of dopamine receptor antagonism and amphetamine-induced psychomotor sensitization on sign- and goal-tracking after extended training
(Elsevier, 2021-03-17)The dopamine system is important for incentive salience attribution, where motivational value is assigned to conditioned cues that predict appetitive reinforcers. However, the role of dopamine in this process may change with extended training. We tested ... -
An eikonal approach for the initiation of reentrant cardiac propagation in reaction-diffusion models
(Institute of electrical and electronics engineers, 2010-05-27)Microscale electrical propagation in the heart can be modeled by a reaction-diffusion system describing cell and tissue electrophysiology. Macroscale features of wavefront propagation can be reproduced by an eikonal model, a reduced formulation involving ... -
Eikonal equation : computation
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Eikonal-based initiation of fibrillatory activity in thin-walled cardiac propagation models
(American Institute of Physics, 2011-12-22)Reentrant arrhythmias can be simulated in electrophysiological models of electrical impulse propagation governed by a reaction-diffusion system. To facilitate the initiation of a large number of independent episodes of simulated arrhythmias with ... -
An eikonal-diffusion solver and its application to the interpolation and the simulation of reentrant cardiac activations
(Elsevier, 2012)Electrical propagation of the cardiac impulse in the myocardium can be described by the eikonal-diffusion equation. This equation governs the field of activation times in a domain where conduction properties are specified. This approach has been applied ... -
Equivalent dipole sources to estimate the influence of extracellular myocardial anisotropy in thin-walled cardiac forward models
(Elsevier, 2017)The extracellular domain of the heart is anisotropic, which affects volume conduction and therefore body surface potentials. This paper tests the hypothesis that when wall thickness is sufficiently small (such as in the atria), the effect of extracellular ... -
Estimation of the QT-RR relation : trade-off between goodness-of-fit and extrapolation accuracy
(IOP Publishing, 2017-02-03)Correction of the QT interval in the ECG for changes in heart rate (RR interval) is needed to compare groups of patients and assess the risk of sudden cardiac death. The QTc represents the QT interval at 60 bpm, although most patients typically have a ... -
Evaluation of a subject-specific transfer-function-based nonlinear QT interval rate-correction method
(IOP Publishing, 2011-04-15)The QT interval in the electrocardiogram (ECG) is a measure of total duration of depolarization and repolarization. Correction for heart rate is necessary to provide a single intrinsic physiological value that can be compared between subjects and within ...