Now showing items 1-20 of 48

  • The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection 

    Dieudé, Mélanie; Bell, Christina; Turgeon, Julie; Beillevaire, Déborah; Yang, Bing; Hamelin, Katia; Qi, Shijie; Pallet, Nicolas; Béland, Chanel; Dhahri, Wahiba; Cailhier, Jean-François; Rousseau, Matthieu; Duchez, Anne-Claire; Lévesque, Tania; Lau, Arthur; Rondeau, Christiane; Gingras, Diane; Muruve, Danie; Rivard, Alain; Cardinal, Héloïse; Perreault, Claude; Desjardins, Michel; Boilard, Éric; Thibault, Pierre; Hébert, Marie-Josée (American Association for the Advancement of Science, 2015-12-16)
    Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies, contribute to rejection in organ transplant recipients. However, mechanisms of immunization to apoptotic components remain largely uncharacterized. We used large-scale ...
  • Active nuclear import and cytoplasmic retention of activation-induced deaminase 

    Patenaude, Anne-Marie; Orthwein, Alexandre; Hu, Yi; Campo, Vanina A.; Kavli, Bodil; Buschiazzo, Alejandro; Di Noia, Javier M. (2009)
    The enzyme activation-induced deaminase (AID) triggers antibody diversification in B cells by catalyzing deamination and consequently mutation of immunoglobulin genes. To minimize off-target deamination, AID is restrained by several regulatory mechanisms ...
  • Adhesion and transcellular migration of neutrophils and B lymphocytes on fibroblasts 

    Couture, Patrick; Paradis-Massie, Jérémie; Oualha, Nadia; Thibault, Gaétan (2009)
    During tissue inflammation, infiltrated leukocytes may have physical contacts with fibroblasts. We observed that neutrophils and B lymphocytes adhered in a larger proportion than T cells on cultured fibroblasts. Microscopy showed that adhesion was also ...
  • Albumin dialysis : a new therapeutic strategy for intoxication from protein-bound drugs 

    Sen, Sambit; Ytrebø, Lars M.; Rose, Christopher; Fuskevaag, Ole-Martin; Davies, Nathan A.; Nedredal, Geir I.; Williams, Roger; Revhaug, Arthur; Jalan, Rajiv (Springer, 2004-01-21)
    Abstract Objective: Although water-soluble drugs can be removed by haemofiltration/haemodialysis, morbidity and mortality from intoxication with protein-bound drugs remains high. The present study investigates whether albumin dialysis in the form of ...
  • Ammonia : this is not the end but rather the end of the beginning 

    Weiss, Nicolas; Dam, Gitte; Rose, Christopher (Elsevier, 2018-04)
    Hepatic encephalopathy (HE) represents a wide spectrum of neurological or neuropsychological symptoms caused by liver disease and/or portosystemic shunts. The major role of hyperammonemia in association with systemic inflammation and oxidative stress ...
  • Ammonia toxicity: from head to toe? 

    Dasarathy, Srinivasan; Mookerjee, Rajeshwar P.; Rackayova, Veronika; Rangroo Thrane, Vinita; Vairappan, Balasubramaniyan; Ott, Peter; Rose, Christopher (Springer, 2016-12)
    Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that the toxic ramifications of ammonia primarily touch the brain and cause ...
  • Ammonia‐lowering strategies for the treatment of hepatic encephalopathy 

    Rose, Christopher (Wiley, 2012-08-08)
    Hyperammonemia leads to neurotoxic levels of brain ammonia and is a major factor involved in the pathogenesis of hepatic encephalopathy (HE). Ammonia‐lowering treatments primarily involve two strategies: inhibiting ammonia production and/or increasing ...
  • The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure : a nested case–control study 

    Karvellas, Constantine J.; Speiser, Jaime L.; Tremblay, Mélanie; Lee, William M.; Rose, Christopher (Springer, 2017)
    Background: Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with signifcant mortality due to intracranial hypertension (ICH), a result of cerebral edema (CE) and astrocyte swelling. Brain-type fatty acid-binding protein (FABP7) ...
  • Astrocyte glutamine synthetase : pivotal in health and disease 

    Rose, Christopher; Verkhratsky, Alexei; Parpura, Vladimir (Portland Press, 2013)
    The multifunctional properties of astrocytes signify their importance in brain physiology and neurological function. In addition to defining the brain architecture, astrocytes are primary elements of brain ion, pH and neurotransmitter homoeostasis. GS ...
  • Autophagy drives fibroblast senescence through MTORC2 regulation 

    Autophagy, senescence and myofibroblast differentiation
    Bernard, Monique; Yang, Bing; Migneault, Francis; Turgeon, Julie; Dieudé, Mélanie; Olivier, Marc-Alexandre; Cardin, Guillaume B.; El-Diwany, Mostafa; Underwood, Katy; Rodier, Francis; Hébert, Marie-Josée (Taylor & Francis, 2020-01-13)
    Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means of responding to long-term cellular stress, has also been linked to myofibroblast differentiation and fibrosis. Here, ...
  • The bile duct ligated rat : a relevant model to study muscle mass loss in cirrhosis 

    Bosoi, Cristina R.; Macedo de Oliveira, Mariana; Ochoa-Sanchez, Rafael; Tremblay, Mélanie; Ten Have, Gabriella A.; Deutz, Nicolaas E. P.; Rose, Christopher; Bémeur, Chantal (Springer, 2016-12)
    Muscle mass loss and hepatic encephalopathy (complex neuropsychiatric disorder) are serious complications of chronic liver disease (cirrhosis) which impact negatively on clinical outcome and quality of life and increase mortality. Liver disease leads ...
  • Brain edema : a valid endpoint for measuring hepatic encephalopathy? 

    Bémeur, Chantal; Cudalbu, Cristina; Dam, Gitte; Thrane, Alexander S.; Cooper, Arthur J. L.; Rose, Christopher (2016-06)
    Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition ...
  • CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells 

    Lapointe, Réjean; Bellemare-Pelletier, Angélique; Housseau, Frank; Thibodeau, Jacques; Hwu, Patrick (HighWire Press (American Association for Cancer Research), 2003-06-01)
    Although they are considered as antigen presenting cells (APC), the role of antigen-unspecific B-lymphocytes in antigen presentation and T lymphocyte stimulation remains controversial. In this paper, we tested the capacity of normal human peripheral ...
  • Computational prediction of neural progenitor cell fates 

    Cohen, Andrew R.; Gomes, F.L.A.F.; Roysam, B.; Cayouette, M. (2010)
    Understanding how stem and progenitor cells choose between alternative cell fates is a major challenge in developmental biology. Efforts to tackle this problem have been hampered by the scarcity of markers that can be used to predict cell division ...
  • Development and disease of the photoreceptor cilium 

    Ramamurthy, V.; Cayouette, M. (2009)
    Primary cilia are microtubule-rich hair-like extensions protruding from the surface of most post-mitotic cells. They act as sensory organelles that help interpret various environmental cues. Mutations in genes encoding proteins involved in ciliogenesis ...
  • Elevated cerebral lactate : implications in the pathogenesis of hepatic encephalopathy 

    Bosoi, Cristina R.; Rose, Christopher (Springer, 2014-06-11)
    Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation, but also in the brain. ...
  • Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure 

    Karvellas, Constantine J.; Speiser, Jaime L.; Tremblay, Mélanie; Lee, William M.; Rose, Christopher (Wiley, 2017-01-19)
    Background/Aim Acetaminophen (APAP)-induced Acute Liver Failure (ALF) is associated with significant mortality. Traditional prognostic scores lack sensitivity. Hypothesis: Serum Liver-type Fatty Acid Binding Protein (FABP1) early (day 1) or late (day ...
  • Elevated serum liver-type fatty acid binding protein levels in non-acetaminophen acute liver failure patients with organ dysfunction. 

    Karvellas, Constantine J.; Speiser, Jaime L.; Tremblay, Mélanie; Lee, William M.; Rose, Christopher (Springer, 2020-03-03)
    Liver-type fatty acid binding protein (FABP1) has previously been demonstrated to improve prognostic discrimination in acetaminophen (APAP)-induced ALF but has not been investigated in other etiologies of ALF. AIM: To determine ...
  • Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis 

    Fortea, José I.; Zipprich, Alexander; Fernandez‐Mena, Carolina; Puerto, Marta; Bosoi, Cristina R.; Almagro, Jorge; Hollenbach, Marcus; Bañares, Juan; Rodríguez‐Sánchez, Belén; Cercenado, Emilia; Clément, Marc‐André; Rose, Christopher; Bañares, Rafael; Vaquero, Javier; Ripoll, Cristina (Wiley, 2017-06-30)
    Background & Aims Recent studies suggest that heparins reduce liver fibrosis and the risk of decompensation of liver disease. Here, we evaluated the effects of enoxaparin in several experimental models of advanced cirrhosis. Methods Cirrhosis was ...
  • The euchromatic and heterochromatic landscapes are shaped by antagonizing effects of transcription on H2A.Z deposition 

    Hardy, Sara; Jacques, Pierre-Étienne; Gévry, Nicolas; Forest, Audrey; Fortin, Marie-Ève; Laflamme, Liette; Gaudreau, Luc; Robert, François (2009)
    A role for variant histone H2A.Z in gene expression is now well established but little is known about the mechanisms by which it operates. Using a combination of ChIP-chip, knockdown and expression profiling experiments, we show that upon gene induction, ...