Parcourir Faculté de médecine par sujet "Origin firing"
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Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma
(Nature Research, 2020-07-20)The mechanisms generating cancer-initiating mutations are not well understood. Sonic hedgehog (SHH) pathway activation is frequent in medulloblastoma (MB), with PTCH1 mutations being a common initiating event. Here we investigated the role of the ...