Parcourir Faculté de médecine par auteur·e "Turgeon, Julie"

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  • The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection 

    Dieudé, Mélanie; Bell, Christina; Turgeon, Julie; Beillevaire, Déborah; Yang, Bing; Hamelin, Katia; Qi, Shijie; Pallet, Nicolas; Béland, Chanel; Dhahri, Wahiba; Cailhier, Jean-François; Rousseau, Matthieu; Duchez, Anne-Claire; Lévesque, Tania; Lau, Arthur; Rondeau, Christiane; Gingras, Diane; Muruve, Danie; Rivard, Alain; Cardinal, Héloïse; Perreault, Claude; Desjardins, Michel; Boilard, Éric; Thibault, Pierre; Hébert, Marie-Josée (American Association for the Advancement of Science, 2015-12-16)
    Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies, contribute to rejection in organ transplant recipients. However, mechanisms of immunization to apoptotic components remain largely uncharacterized. We used large-scale ...

  • Apoptotic exosome-like vesicles transfer specific and functional mRNAs to endothelial cells by phosphatidylserine-dependent macropinocytosis 

    Brodeur, Alexandre; Migneault, Francis; Lanoie, Maude; Beillevaire, Déborah; Turgeon, Julie; Karakeussian Rimbaud, Annie; Thibodeau, Nicolas; Boilard, Éric; Dieudé, Mélanie; Hébert, Marie-Josée (Springer Nature, 2023-07-20)
    Apoptosis of endothelial cells prompts the release of apoptotic exosome-like vesicles (ApoExos), subtype extracellular vesicles secreted by apoptotic cells after caspase-3 activation. ApoExos are different from both apoptotic bodies and classical ...

  • Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes 

    Beillevaire, Déborah; Migneault, Francis; Turgeon, Julie; Gingras, Diane; Karakeussian Rimbaud, Annie; Marcoux, Geneviève; Spino, Crysta; Thibodeau-Jarry, Nicolas; Bonneil, Eric; Thibault, Pierre; Boilard, Éric; Dieudé, Mélanie; Hébert, Marie-Josée (Springer Nature, 2022-02-11)
    Apoptotic exosome-like vesicles (ApoExos) are a novel type of extracellular vesicle that contribute to the propagation of inflammation at sites of vascular injury when released by dying cells. ApoExos are characterized by the presence of the C-terminal ...

  • Autophagy drives fibroblast senescence through MTORC2 regulation 

    Autophagy, senescence and myofibroblast differentiation
    Bernard, Monique; Yang, Bing; Migneault, Francis; Turgeon, Julie; Dieudé, Mélanie; Olivier, Marc-Alexandre; Cardin, Guillaume B.; El-Diwany, Mostafa; Underwood, Katy; Rodier, Francis; Hébert, Marie-Josée (Taylor & Francis, 2020-01-13)
    Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means of responding to long-term cellular stress, has also been linked to myofibroblast differentiation and fibrosis. Here, ...

  • Caspase-3 dependent peritubular capillary dysfunction is pivotal for transition from acute to chronic kidney disease after acute ischemia-reperfusion injury 

    Lan, Shanshan; Yang, Bing; Migneault, Francis; Turgeon, Julie; Bourgault, Maude; Dieudé, Mélanie; Cardinal, Héloïse; Hickey, Michael; Patey, Natacha; Hébert, Marie-Josée (American Physiological Society, 2021-08-02)
    Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Caspase-3, an effector responsible for apoptosis execution, is activated within peritubular capillary (PTC) in the early stage of IRI-induced acute kidney injury (AKI). ...

  • Modulation de la néovascularisation post-ischémique en présence de facteurs de risque cardiovasculaire 

    Turgeon, Julie (2012-05-03)
    L’athérosclérose est la principale cause d’infarctus du myocarde, de mort subite d’origine cardiaque, d’accidents vasculaires cérébraux et d’ischémie des membres inférieurs. Celle-ci cause près de la moitié des décès dans les pays industrialisés. Lorsque ...