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The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection
(American Association for the Advancement of Science, 2015-12-16)Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies, contribute to rejection in organ transplant recipients. However, mechanisms of immunization to apoptotic components remain largely uncharacterized. We used large-scale ...