Browsing Faculté de médecine by Affiliation "Université de Montréal. Faculté de médecine. Département de pharmacologie et physiologie"
Now showing items 21-40 of 56
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Extraction and analysis of T waves in electrocardiograms during atrial flutter
(Institute of electrical and electronics engineers, 2010-12-13)Analysis of T waves in the electrocardiogram (ECG) is an essential clinical tool for diagnosis, monitoring and followup of patients with heart dysfunction. During atrial flutter, this analysis has been so far limited by the perturbation of flutter waves ... -
Finite volume stiffness matrix for solving anisotropic cardiac propagation in 2-D and 3-D unstructured meshes
(Institute of electrical and electronics engineers, 2005-07-11)The finite volume method (FVM) has been shown recently to be an effective method for discretizing the reaction-diffusion equations that govern wavefront propagation in anisotropic cardiac tissue, as it can naturally handle both complex geometries and ... -
Fitting local repolarization parameters in cardiac reaction-diffusion models in the presence of electrotonic coupling
(Elsevier, 2017)Background: Repolarization gradients contribute to arrhythmogenicity. In reaction–diffusion models of cardiac tissue, heterogeneities in action potential duration (APD) can be created by locally modifying an intrinsic membrane kinetics parameter. ... -
Geometrical measurement of cardiac wavelength in reaction-diffusion models
(American Institute of Physics, 2014)The dynamics of reentrant arrhythmias often consists in multiple wavelets propagating throughout an excitable medium. An arrhythmia can be sustained only if these reentrant waves have a sufficiently short wavelength defined as the distance traveled ... -
Have we reproduced Rat Park? Conceptual but not direct replication of the protective effects of social and environmental enrichment in addiction
(Neuroscience Center HiLife, 2020-08-13)The Rat Park studies are classic experiments in addiction neuroscience, yet they have not been successfully replicated directly and several serious methodological criticisms have been raised. However, the conceptual reproducibility of the Rat Park ... -
How fast and how often: the pharmacokinetics of drug use are decisive in addiction
(2015-09)How much, how often and how fast a drug reaches the brain determine the behavioural and neuroplastic changes associated with the addiction process. Despite the critical nature of these variables, the drug addiction field often ignores pharmacokinetic ... -
Metabotropic group II glutamate receptors in the basolateral amygdala mediate cue-triggered increases in incentive motivation
(Springer, 2021-07-05)Rationale: Reward-associated cues can trigger incentive motivation for reward and invigorate reward-seeking behaviour via Pavlovian-to-instrumental transfer (PIT). Glutamate signaling within the basolateral amygdala (BLA) modulates cue-triggered increases ... -
Modeling atrial arrhythmias : impact on clinical diagnosis and therapies
(Institute of electrical and electronics engineers, 2008)Atrial arrhythmias are the most frequent sustained rhythm disorders in humans and often lead to severe complications such as heart failure and stroke. Despite the important insights provided by animal models into the mechanisms of atrial arrhythmias, ... -
Modeling atrial fibrillation : from myocardial cells to ECG
Modeling AF : from myocardial cells to ECG
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Modeling left and right atrial contributions to the ECG : a dipole-current source approach
(Elsevier, 2015)This paper presents the mathematical formulation, the numerical validation and several illustrations of a forward-modeling approach based on dipole-current sources to compute the contribution of a part of the heart to the electrocardiogram (ECG). ... -
Modeling of atrial fibrillation
(Wiley, 2012-12-18)Computer modeling of atrial fibrillation (AF) is considered today as a potentially effective tool for better understanding AF mechanisms and for the development of therapeutic options. Computer models are based on an integrative approach, from the ... -
Moment arms of the deltoid, infraspinatus and teres minor muscles for movements with high range of motion : a cadaveric study
(Elsevier, 2022-05-25)Background Moment arms are an indicator of the role of the muscles in joint actuation. An excursion method is often used to calculate them, even though it provides 1D results. As shoulder movement occurs in three dimensions (combination of flexion, ... -
Moving horizon estimation of human kinematics and muscle forces
(Institute of electrical and electronics engineers, 2023-07-04)Human-robot interaction based on real-time kinematics or electromyography (EMG) feedback improves rehabilitation using assist-as-needed strategies. Muscle forces are expected to provide even more comprehensive information than EMG to control these ... -
Multiparameter optimization of nonuniform passive diffusion properties for creating coarse-grained equivalent models of cardiac propagation
(Elsevier, 2021-09-10)The arrhythmogenic role of discrete cardiac propagation may be assessed by comparing discrete (fine-grained) and equivalent continuous (coarse-grained) models. We aim to develop an optimization algorithm for estimating the smooth conductivity field ... -
Neuroscience publishing is too important to leave to publishers
(Episteme Health Inc., 2019-06)Almost every open access neuroscience journal is pay-to-publish. This leaves neuroscientists with a choice of submitting to journals that not all of our colleagues can legitimately access and choosing to pay large sums of money to publish open access. ... -
A numerical scheme for modeling wavefront propagation on a monolayer of arbitrary geometry
(Institute of electrical and electronics engineers, 2003-04-15)The majority of models of wavefront propagation in cardiac tissue have assumed relatively simple geometries. Extensions to complicated three-dimensional (3-D) representations are computationally challenging due to issues related both to problem size ... -
Optimal estimation of complex aerial movements using dynamic optimization
(Routledge, 2022-06-01)When estimating full-body motion from experimental data, inverse kinematics followed by inverse dynamics does not guarantee dynamical consistency of the resulting motion, especially in movements where the trajectory depends heavily on the initial state, ... -
Optimal forward twisting pike somersault without self-collision
(Routledge & International Society of Biomechanics in Sports, 2022-03-23)In acrobatic sports, twisting fast before piking allows athletes to enlarge their scoring potential. Since planning the arm and hip movements to twist fast is unintuitive, optimal control appears as a powerful and risk-free tool. To our knowledge, ... -
Pacemaker activity resulting from the coupling with nonexcitable cells
(American Physical Society, 2006-07-14)Fibroblasts are nonexcitable cells that are sometimes coupled with excitable cells (cardiomyocytes). Due to a higher resting potential, these cells may act as a current source or sink and therefore disturb the electrical activity of the surrounding ... -
Phase singularity detection through phase map interpolation : theory, advantages and limitations
(Elsevier, 2018-07-24)Background During a cardiac arrhythmia, reentrant waves rotate around critical points called phase singularities (PS). PS detection is relevant to the quantitative description of the dynamics and to the identification of potential targets for ablation. ...