Parcourir Faculté de médecine par affiliation "Université de Montréal. Faculté de médecine. Département de médecine"
Voici les éléments 21-40 de 83
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Brain edema : a valid endpoint for measuring hepatic encephalopathy?
(2016-06)Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition ... -
Caspase-3 dependent peritubular capillary dysfunction is pivotal for transition from acute to chronic kidney disease after acute ischemia-reperfusion injury
(American Physiological Society, 2021-08-02)Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Caspase-3, an effector responsible for apoptosis execution, is activated within peritubular capillary (PTC) in the early stage of IRI-induced acute kidney injury (AKI). ... -
CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells
(HighWire Press (American Association for Cancer Research), 2003-06-01)Although they are considered as antigen presenting cells (APC), the role of antigen-unspecific B-lymphocytes in antigen presentation and T lymphocyte stimulation remains controversial. In this paper, we tested the capacity of normal human peripheral ... -
Computational prediction of neural progenitor cell fates
(2010)Understanding how stem and progenitor cells choose between alternative cell fates is a major challenge in developmental biology. Efforts to tackle this problem have been hampered by the scarcity of markers that can be used to predict cell division ... -
Decreased progenitor TCF1 + T-cells correlate with COVID-19 disease severity
(Nature research, 2024-05-03)COVID-19, caused by SARS-CoV-2, can lead to a severe inflammatory disease characterized by significant lymphopenia. However, the underlying cause for the depletion of T-cells in COVID-19 patients remains incompletely understood. In this study, we ... -
Development and disease of the photoreceptor cilium
(2009)Primary cilia are microtubule-rich hair-like extensions protruding from the surface of most post-mitotic cells. They act as sensory organelles that help interpret various environmental cues. Mutations in genes encoding proteins involved in ciliogenesis ... -
Doppler renal resistance index for the prediction of response to passive leg-raising following cardiac surgery
(Wiley, 2018-03-25)Purpose: Doppler-based renal resistance index (RI) can be measured at the bedside of critically illpatients. This study was designed to assess if the RI predicted an increase in cardiac output (CO)following passive leg-raising (PLR) in patients admitted ... -
Elevated cerebral lactate : implications in the pathogenesis of hepatic encephalopathy
(Springer, 2014-06-11)Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation, but also in the brain. ... -
Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure
(Wiley, 2017-01-19)Background/Aim Acetaminophen (APAP)-induced Acute Liver Failure (ALF) is associated with significant mortality. Traditional prognostic scores lack sensitivity. Hypothesis: Serum Liver-type Fatty Acid Binding Protein (FABP1) early (day 1) or late (day ... -
Elevated serum liver-type fatty acid binding protein levels in non-acetaminophen acute liver failure patients with organ dysfunction.
(Springer, 2020-03-03)Liver-type fatty acid binding protein (FABP1) has previously been demonstrated to improve prognostic discrimination in acetaminophen (APAP)-induced ALF but has not been investigated in other etiologies of ALF. AIM: To determine ... -
Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis
(Wiley, 2017-06-30)Background & Aims Recent studies suggest that heparins reduce liver fibrosis and the risk of decompensation of liver disease. Here, we evaluated the effects of enoxaparin in several experimental models of advanced cirrhosis. Methods Cirrhosis was ... -
The euchromatic and heterochromatic landscapes are shaped by antagonizing effects of transcription on H2A.Z deposition
(2009)A role for variant histone H2A.Z in gene expression is now well established but little is known about the mechanisms by which it operates. Using a combination of ChIP-chip, knockdown and expression profiling experiments, we show that upon gene induction, ... -
L’évolution d’une coopération bibliothéconomique dans le secteur de la santé: le consortium des ressources électroniques du RUIS de l’UdeM
(AIFBD, 2009)Sous l’impulsion de la Loi 83, loi modifiant la Loi sur les services de santé et les services sociaux et d’autres dispositions législatives, sanctionnée en 2005, et fort d’une expérience issue d’une coopération de plus de 30 ans entre les bibliothèques ... -
Excessive intragastric alcohol administration exacerbates hepatic encephalopathy and provokes neuronal cell death in male rats with chronic liver disease
(Wiley, 2024-04-29)Hepatic encephalopathy (HE) is defined as decline in neurological function during chronic liver disease (CLD). Alcohol is a major etiological factor in the pathogenesis of fibrosis/cirrhosis and has also been documented to directly impact the brain. ... -
Exercise training can attenuate preeclampsia-like features in an animal model
Exercise training can attenuate preeclampsia-like symptoms in an animal model.
(Lippincott, Williams and Wilkins, 2010-12)Objective: Exercise training benefits have been widely investigated and used as alternative treatment for different pathological conditions. Since preeclampsia is a severe pregnancy-associated disease for which no treatment is available, our aim was ... -
Genetically engineered E. coli Nissle attenuates hyperammonemia and prevents memory impairment in bile‐duct ligated rats
(Wiley, 2021-02-06)Hyperammonemia associated with chronic liver disease (CLD) is implicated in the pathogenesis of hepatic encephalopathy (HE). The gut is a major source of ammonia production that contributes to hyperammonemia in CLD and HE and remains the primary ... -
Glycine and hyperammonemia : potential target for the treatment of hepatic encephalopathy
(Springer, 2016-06-23)Hepatic encephalopathy (HE) is a neuropsychiatric disorder caused by hepatic dysfunction. Numerous studies dictate that ammonia plays an important role in the pathogenesis of HE, and hyperammonemia can lead to alterations in amino acid homeostasis. ... -
GWAS of hematuria
GWAS of non-genitourinary hematuria
GWAS reveals hematuria mechanisms(American Society of Nephrology, 2022-05-01)Background and objectives Glomerular hematuria has varied causes but can have a genetic basis, including Alport syndrome and IgA nephropathy. Design, setting, participants, & measurements We used summary statistics to identify genetic variants ...