Browsing Faculté de médecine by Affiliation "Université de Montréal. Faculté de médecine. Département de psychiatrie et d'addictologie"
Now showing items 1-20 of 81
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A 12-week open-label, multicenter study evaluating the safety and patient-reported efficacy of sodium oxybate in patients with narcolepsy and cataplexy
(Elsevier, 2015)Objective: This study aimed to evaluate safety and efficacy of sodium oxybate (SXB) titrated to effect. Methods: SXB-naive patients who had participated in a randomized SXB clinical trial and had not been titrated to adequate clinical effect were ... -
3D Cohort Study : The Integrated Research Network in Perinatology of Quebec and Eastern Ontario
(Wiley, 2016)Background: The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children. Methods: Pregnant ... -
The 3D-Transition study : objectives, methods, and implementation of an innovative planned missing data design
(Oxford University Press, 2021-05-12)The prevalence of mental health problems represents a significant burden on school and community health resources as early as preschool. Reducing this burden requires a better understanding of the developmental mechanisms linking children’s early ... -
Abstracts of posters and platform sessions accepted for virtual presentation at the 2020 Annual Meeting of the Society for developmental and behavioral pediatrics. Pubertal development and adolescent alcohol use : a prospective study on the role of sensation seeking and impulsivity. Abstract 46
(Lippincott, Williams & Wilkins, 2021-02-01) -
Analysis of common and rare VPS13C variants in late-onset Parkinson disease
(Lippincott, Williams and Wilkins, 2020-01-09)Objective We aimed to study the role of coding VPS13C variants in a large cohort of patients with lateonset Parkinson disease (PD) (LOPD). Methods VPS13C and its untranslated regions were sequenced using targeted next-generation sequencing in 1,567 ... -
Association between recurrent dreams, disturbing dreams and suicidal ideation in adolescents
(American Psychological Association, 2021)Disturbing dreams and recurrent dreams have both been linked to a wide range of psychological difficulties in children. There is growing evidence that the experience of frequent disturbing dreams is associated with suicidal ideation in adults but studies ... -
Association of protein phosphatase PPM1G with alcohol use disorder and brain activity during behavioral control in a genome-wide methylation analysis
(American Psychiatric Publishing, 2015-06)OBJECTIVE: The genetic component of alcohol use disorder is substantial, but monozygotic twin discordance indicates a role for nonheritable differences that could be mediated by epigenetics. Despite growing evidence associating epigenetics and psychiatric ... -
Associations of prenatal urinary bisphenol a concentrations with child behaviors and cognitive abilities
(National Institute of Environmental Health Sciences, 2017)BACKGROUND: Prenatal bisphenol A (BPA) exposure has been associated with adverse neurodevelopment in epidemiological studies. However, prior studies had limited statistical power to examine sex-specific effects, and few examined child cognition. OBJECTIVES: ... -
BDNF Val66Met polymorphism interacts with sleep consolidation to predict ability to create new declarative memories
(Society for Neuroscience, 2016-08)It is hypothesized that a fundamental function of sleep is to restore an individual's day-to-day ability to learn and to constantly adapt to a changing environment through brain plasticity. Brain-derived neurotrophic factor (BDNF) is among the key ... -
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents
(Nature Research, 2017-02-21)Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability ... -
Cannabidiol as a treatment for craving and relapse in individuals with cocaine use disorder : a randomized placebo‐controlled trial
(Wiley, 2021-01-19)Background and Aims Cocaine use disorder (CUD) is a significant public health concern for which no efficacious pharmacological interventions are available. Cannabidiol (CBD) has attracted considerable interest as a promising treatment for addiction. ... -
Cannabis use in early adolescence: evidence of amygdala hypersensitivity to signals of threat
(Elsevier, 2015-12)Cannabis use in adolescence may be characterized by differences in the neural basis of affective processing. In this study, we used an fMRI affective face processing task to compare a large group (n = 70) of 14-year olds with a history of cannabis use ... -
Children’s cortisol response to the transition from preschool to formal schooling : a review
(Elsevier, 2018-09-14)This review examines the current state of knowledge regarding children's biological stress response during the transition from preschool to compulsory formal schooling, focusing on longitudinal studies that include repeated measures of cortisol ... -
Chronic stress, cognitive functioning and mental health
(Elsevier, 2011-03-02)This review aims to discuss the evidence supporting the link between chronic stress, cognitive function and mental health. Over the years, the associations between these concepts have been investigated in different populations. This review summarizes ... -
Co-morbidity between gambling problems and depressive symptoms: A longitudinal perspective of risk and protective factors
(Springer Verlag, 2016)In both adolescents and adults, gambling problems and depressive symptoms co-occur and share some common risk factors (e.g., impulsivity and socio-family risk). However, little is known about (1) the developmental course of the co-morbidity of these ... -
Common genetic variants influence human subcortical brain structures
(Nature Research, 2015-04-09)The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal ... -
Comorbid development of disruptive behaviors from age 1½ to 5 years in a population birth-cohort and association with school adjustment in first grade
Comorbidity of Disruptive Behaviors from age 1½ to 5 years
(Springer Verlag, 2016-05)Comorbidity is frequent among disruptive behaviors (DB) and leads to mental health problems during adolescence and adulthood. However, the early developmental origins of this comorbidity have so far received little attention. This study investigated ... -
The content of recurrent dreams in young adolescents
(Elsevier, 2015-12)Studies on children’s recurrent dreams have been largely anecdotal and based on adults’ recollections of dreams experienced during childhood. We collected 102 reports of recurrent dreams from a sample of young adolescents aged between 11 and 15 years ... -
Correlated gene expression supports synchronous activity in brain networks
(American Association for the Advancement of Science, 2015-06-12)During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional ... -
Correlation of changes in patient-reported quality of life with physician-rated global impression of change in patients with narcolepsy participating in a clinical trial of sodium oxybate : a post hoc analysis
(Springer, 2017-07-13)Introduction: Narcolepsy patients report lower health-related quality of life (HRQoL) than the general population, as measured by the Short Form-36 Health Survey (SF-36). This analysis evaluated whether changes in SF-36 correlated with physician-rated ...