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dc.contributor.authorRhouma, Mohamed
dc.contributor.authorBeaudry, Francis
dc.contributor.authorThériault, William
dc.contributor.authorBergeron, Nadia
dc.contributor.authorLaurent-Lewandowski, Sylvette
dc.contributor.authorFairbrother, John Morris
dc.contributor.authorLetellier, Ann
dc.date.accessioned2016-01-12T15:20:25Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2016-01-12T15:20:25Z
dc.date.issued2015-10
dc.identifier.citationRhouma, M., Beaudry, F., Thériault, W., Bergeron, N., Laurent-Lewandowski, S., Fairbrother, J.M., Letellier, A. (2015, October). Gastric stability and oral bioavailability of colistin sulfate in pigs challenged or not with Escherichia coli O149: F4 (K88). Research in veterinary science, 102, 173-181.fr
dc.identifier.urihttp://hdl.handle.net/1866/12859
dc.subjectColistin sulfatefr
dc.subjectPigsfr
dc.subjectE. colifr
dc.subjectGastric stabilityfr
dc.subjectAntimicrobial activityfr
dc.subjectIntestinal absorptionfr
dc.titleGastric stability and oral bioavailability of colistin sulfate in pigs challenged or not with Escherichia coli O149: F4 (K88)fr
dc.typeArticle
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine vétérinairefr
UdeM.statutProfesseur(e) / Professorfr
dc.identifier.doi10.1016/j.rvsc.2015.08.005
dcterms.abstractThe aim of the present study was to investigate the in vitro gastric stability of colistin sulfate (CS) and its antimicrobial activity against Escherichia coli and to study the impact of ETEC O149: F4 (K88) infection in pigs on CS intestinal absorption. The stability profile of CS was evaluated in a simulated gastric fluid (SGF). Antimicrobial activity of CS and its degradation products were examined in a 96-well polystyrene microplate model. The effect of experimental infection with ETEC O149: F4 on CS intestinal absorption was determined by quantification of CS systemic concentration using a validated LC–MS/MS method. A rapid degradation of CS accompanied by an increase in CS antimicrobial activity by comparison with non-degraded CS (P < 0.0001) was observed in SGF. Additionally, CS levels were not quantifiable in systemic circulation using a highly sensitive method and concurrent oral challenge did not affect CS absorption in an induction model of subclinical post-weaning diarrhea (PWD).fr
dcterms.bibliographicCitationResearch in veterinary science ; vol. 102
dcterms.isPartOfurn:ISSN:0034-5288
dcterms.isPartOfurn:ISSN:1532-2661
dcterms.languageengfr
UdeM.VersionRioxxVersion originale de l'auteur / Author's Original


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