Clinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysis
dc.contributor.author | Discepola, Vanessa | |
dc.contributor.author | Schnitzer, Mireille | |
dc.contributor.author | Jolicoeur, Marc | |
dc.contributor.author | Rousseau, Guy | |
dc.contributor.author | Lordkipanidzé, Marie | |
dc.date.accessioned | 2018-10-29T18:42:32Z | |
dc.date.available | MONTHS_WITHHELD:12 | fr |
dc.date.available | 2018-10-29T18:42:32Z | |
dc.date.issued | 2018-10-22 | |
dc.identifier.uri | http://hdl.handle.net/1866/21035 | |
dc.publisher | Taylor & Francis | fr |
dc.subject | Acute coronary syndrome | fr |
dc.subject | Bleeding | fr |
dc.subject | Ischemia | fr |
dc.subject | Major adverse cardiac events | fr |
dc.subject | Mortality | fr |
dc.subject | Thrombocytopenia | fr |
dc.title | Clinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysis | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de pharmacie | fr |
dc.identifier.doi | 10.1080/09537104.2018.1528348 | |
dcterms.abstract | Thrombocytopenia (TP) is common in hospitalized patients. In the context of acute coronary syndromes (ACS), TP has been linked to adverse clinical outcomes. We present a systematic review and meta-analysis of the evidence on the clinical importance of pre-existing and in-hospital acquired TP in the context of ACS. Specifically, we address (a) the prevalence and associated factors with TP in the context of ACS; and (b) the association between TP and all-cause mortality, major adverse cardiovascular events (MACE) and major bleeding. We conducted systematic literature searches in MEDLINE and Web of Science. For the meta-analysis, we fit linear mixed models with a random study-specific intercept for the aggregate outcomes. A total of 16 studies and 190,915 patients were included in this study. Of these patients, 8.8% ± 1.2% presented with pre-existing TP while 5.8% ± 1.0% developed TP after hospital admission. Pre-existing TP was not statistically significantly associated with adverse outcomes. Acquired TP was associated with greater risk of all-cause mortality (risk difference (RD): 4.3%; 95% confidence interval (CI): 2% - 6%; p=0.04), MACE (RD: 8.5%; 95% CI: 1% -16.0%; p=0.037) and major bleeding (RD: 11.9%; 95% CI: 5% - 19%; p=0.005). In conclusion, TP is a prevalent condition in patients admitted for an ACS and identifies a high-risk patient population more likely to experience ischemic and bleeding complications, as well as higher mortality. | fr |
dcterms.alternative | Thrombocytopenia in acute coronary syndromes | fr |
dcterms.isPartOf | urn:ISSN:0953-7104 | fr |
dcterms.isPartOf | urn:ISSN:1369-1635 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | Clinical importance of thrombocytopenia in patients with acute coronary syndromes: a systematic review and meta-analysis. Discepola V, Schnitzer ME, Jolicoeur EM, Rousseau G, Lordkipanidzé M. Platelets. 2018 Oct 22:1-11. doi: 10.1080/09537104.2018.1528348. | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | fr |
oaire.citationTitle | Platelets |
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