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Brain edema : a valid endpoint for measuring hepatic encephalopathy?
(2016-06)
Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of ...
Ammonia toxicity: from head to toe?
(Springer, 2016-12)
Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that the toxic ramifications of ammonia primarily ...
The bile duct ligated rat : a relevant model to study muscle mass loss in cirrhosis
(Springer, 2016-12)
Muscle mass loss and hepatic encephalopathy (complex neuropsychiatric disorder) are serious complications of chronic liver disease (cirrhosis) which impact negatively on clinical outcome and quality of life and increase ...
Implication of hypotension in the pathogenesis of cognitive impairment and brain injury in chronic liver disease
(Springer, 2023-01-13)
The incidence of chronic liver disease is on the rise. One of the primary causes of hospital admissions for patients with cirrhosis is hepatic encephalopathy (HE), a debilitating neurological complication. HE is defined ...
Lessons on brain edema in HE : from cellular to animal models and clinical studies
(Springer, 2023-08-22)
Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations ...
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease
(2014)
The pathogenesis of brain edema in patients with chronic liver disease (CLD) and minimal hepatic encephalopathy (HE) remains undefined. This study evaluated the role of brain lactate, glutamine and organic osmolytes, ...
AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats
(2011)
The pathogenesis of hepatic encephalopathy is multifactorial, involving gut-derived toxins such as ammonia, which has been demonstrated to induce oxidative stress. Therefore, a primary hepatic encephalopathy treatment ...
Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide
(2005-12)
Chronic liver failure leads to hyperammonemia and consequently increased brain ammonia concentrations, resulting in hepatic encephalopathy. When the liver fails to regulate ammonia concentrations, the brain, devoid of a ...
Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress
(2010-03)
Ammonia is neurotoxic and believed to play a major role in the pathogenesis of hepatic encephalopathy (HE). It has been demonstrated, in vitro and in vivo, that acute and high ammonia treatment induces oxidative stress. ...
Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction
(1999)
BACKGROUND & AIMS: Manganese (Mn) deposition could be responsible for the T(1)-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional ...