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Genetically engineered E. coli Nissle attenuates hyperammonemia and prevents memory impairment in bile‐duct ligated rats
(Wiley, 2021-02-06)
Hyperammonemia associated with chronic liver disease (CLD) is implicated in the pathogenesis of hepatic encephalopathy (HE). The gut is a major source of ammonia production that contributes to hyperammonemia in CLD and HE ...
Hepatic encephalopathy : novel insights into classification, pathophysiology and therapy
(Elsevier, 2020-10-21)
Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric abnormalities, from subclinical changes (mild ...
Elevated cerebral lactate : implications in the pathogenesis of hepatic encephalopathy
(Springer, 2014-06-11)
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver
failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation,
but ...
Judging the value of ammonia measurement on lactulose dosing : apples and oranges?
(University of Toronto Press, 2021-02-24)
Heretical thoughts into hepatic encephalopathy
(Elsevier & European Association for the Study of the Liver, 2022-03-27)
Clinical progress in the development of new diagnostic modalities and therapeutic strategies for the management of patients with hepatic encephalopathy has lagged behind the vast knowledge that has been generated from basic ...
Amino acids, ammonia, and hepatic encephalopathy
(Elsevier, 2022-04-30)
Hepatic encephalopathy (HE) is a decline in brain function arising due to liver insufficiency. The liver's diminished capacity to clear ammonia, and the subsequent accumulation of it, is highly implicated in pathogenesis ...
Ammonia toxicity: from head to toe?
(Springer, 2016-12)
Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that the toxic ramifications of ammonia primarily ...
The bile duct ligated rat : a relevant model to study muscle mass loss in cirrhosis
(Springer, 2016-12)
Muscle mass loss and hepatic encephalopathy (complex neuropsychiatric disorder) are serious complications of chronic liver disease (cirrhosis) which impact negatively on clinical outcome and quality of life and increase ...
AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats
(2011)
The pathogenesis of hepatic encephalopathy is multifactorial, involving gut-derived toxins such as ammonia, which has been demonstrated to induce oxidative stress. Therefore, a primary hepatic encephalopathy treatment ...
Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide
(2005-12)
Chronic liver failure leads to hyperammonemia and consequently increased brain ammonia concentrations, resulting in hepatic encephalopathy. When the liver fails to regulate ammonia concentrations, the brain, devoid of a ...