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Genetically engineered E. coli Nissle attenuates hyperammonemia and prevents memory impairment in bile‐duct ligated rats
(Wiley, 2021-02-06)
Hyperammonemia associated with chronic liver disease (CLD) is implicated in the pathogenesis of hepatic encephalopathy (HE). The gut is a major source of ammonia production that contributes to hyperammonemia in CLD and HE ...
Progressive resistance training prevents loss of muscle mass and strength in bile duct‐ligated rats
(Wiley, 2018-11-05)
BACKGROUND: Loss of muscle mass and strength is common in cirrhosis and increases
the risk of hyperammonaemia and hepatic encephalopathy. Resistance training
optimizes muscle mass and strength in several ...
Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats
(Wiley, 2013-11-25)
Background & Aims The pathogenesis of hepatic encephalopathy (HE) is multifactorial and often associated with the
development of brain oedema. In addition to ammonia playing a central role, systemic oxidative stress is ...
The bile duct ligated rat : a relevant model to study muscle mass loss in cirrhosis
(Springer, 2016-12)
Muscle mass loss and hepatic encephalopathy (complex neuropsychiatric disorder) are serious complications of chronic liver disease (cirrhosis) which impact negatively on clinical outcome and quality of life and increase ...
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease
(2014)
The pathogenesis of brain edema in patients with chronic liver disease (CLD) and minimal hepatic encephalopathy (HE) remains undefined. This study evaluated the role of brain lactate, glutamine and organic osmolytes, ...
AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats
(2011)
The pathogenesis of hepatic encephalopathy is multifactorial, involving gut-derived toxins such as ammonia, which has been demonstrated to induce oxidative stress. Therefore, a primary hepatic encephalopathy treatment ...
Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress
(2010-03)
Ammonia is neurotoxic and believed to play a major role in the pathogenesis of hepatic encephalopathy (HE). It has been demonstrated, in vitro and in vivo, that acute and high ammonia treatment induces oxidative stress. ...
Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure
(2012-04)
Chronic liver failure leads to hyperammonemia, a central component in the pathogenesis of hepatic encephalopathy (HE); however, a correlation between blood ammonia levels and HE severity remains controversial. It is believed ...
Excessive intragastric alcohol administration exacerbates hepatic encephalopathy and provokes neuronal cell death in male rats with chronic liver disease
(Wiley, 2024-04-29)
Hepatic encephalopathy (HE) is defined as decline in neurological function during
chronic liver disease (CLD). Alcohol is a major etiological factor in the pathogenesis of
fibrosis/cirrhosis and has also been documented ...