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dc.contributor.advisorHanessian, Stephen
dc.contributor.authorSalinas Hernandez, Juan Carlos
dc.date.accessioned2014-10-08T18:20:59Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2014-10-08T18:20:59Z
dc.date.issued2014-09-29
dc.date.submitted2014-04
dc.identifier.urihttp://hdl.handle.net/1866/11229
dc.subject(S)-cEt-LNAfr
dc.subjectTechnologie antisensfr
dc.subjectNucleosidefr
dc.subjectAntisense technologyfr
dc.subject.otherChemistry - Organic / Chimie organique (UMI : 0490)fr
dc.titleSynthesis of (S)-cEt-LNAfr
dc.typeThèse ou mémoire / Thesis or Dissertation
etd.degree.disciplineChimiefr
etd.degree.grantorUniversité de Montréalfr
etd.degree.levelMaîtrise / Master'sfr
etd.degree.nameM. Sc.fr
dcterms.abstractNucleoside (S)-cEt-LNA a été synthétisé par trois voies différentes à partir de la 5- méthyluridine qui est commercialement disponible. Le chemin le plus court comprend une méthylation diastéréosélective d'un aldéhyde, et une cyclisation 5-exo-tet d'un éther par déplacement SN2.fr
dcterms.abstract(S)-cEt-LNA nucleoside was synthesized by three different routes starting from commercially available 5-methyluridine. The shortest route includes a diastereoselective methylation of an aldehyde, and a 5-exo-tet cylization of an ether via SN2 displacement.fr
dcterms.languageengfr


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