Show item record

dc.contributor.authorBosoi, Cristina R.
dc.contributor.authorRose, Christopher F.
dc.date.accessioned2013-04-28T18:06:51Z
dc.date.available2013-04-28T18:06:51Z
dc.date.issued2009-03
dc.identifier.citationBosoi, C. R. and Rose, C. F. (2009) Identifying the direct effects of ammonia on the brain. Metab Brain Dis 24 (1):95-102en
dc.identifier.urihttp://hdl.handle.net/1866/9593
dc.subjectAmmoniaen
dc.subjectAmmoniacen
dc.subjectBrainen
dc.subjectDéfaillance hépatiqueen
dc.subjectEncéphaleen
dc.subjectEncéphalopathie hépatiqueen
dc.subjectHepatic encephalopathyen
dc.subjectLiver failureen
dc.titleIdentifying the direct effects of ammonia on the brain
dc.typeArticleen
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine. Centre de recherche du CHUM fr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecinefr
dc.identifier.doi10.1007/s11011-008-9112-7
dcterms.abstractElevated concentrations of ammonia in the brain as a result of hyperammonemia leads to cerebral dysfunction involving a spectrum of neuropsychiatric and neurological symptoms (impaired memory, shortened attention span, sleep-wake inversions, brain edema, intracranial hypertension, seizures, ataxia and coma). Many studies have demonstrated ammonia as a major player involved in the neuropathophysiology associated with liver failure and inherited urea cycle enzyme disorders. Ammonia in solution is composed of a gas (NH(3)) and an ionic (NH(4) (+)) component which are both capable of crossing plasma membranes through diffusion, channels and transport mechanisms and as a result have a direct effect on pH. Furthermore, NH(4) (+) has similar properties as K(+) and, therefore, competes with K(+) on K(+) transporters and channels resulting in a direct effect on membrane potential. Ammonia is also a product as well as a substrate for many different biochemical reactions and consequently, an increase in brain ammonia accompanies disturbances in cerebral metabolism. These direct effects of elevated ammonia concentrations on the brain will lead to a cascade of secondary effects and encephalopathy.en
dcterms.bibliographicCitationMetabolic Brain Disease ; 24(1)
dcterms.languageengen
UdeM.VersionRioxxVersion acceptée / Accepted Manuscript


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show item record