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Subcortical amyloid relates to cortical morphology in cognitively normal individuals
(Springer, 2019-07-25)
Purpose Amyloid (Aβ) brain deposition can occur in cognitively normal individuals and is associated with cortical volume
abnormalities. Aβ-related volume changes are inconsistent across studies. Since volume is composed ...
Subcortical amyloid load is associated with shape and volume in cognitively normal individuals
Subcortical Aβ associates to morphometry
(Wiley, 2019-05-21)
Amyloid-beta (Aβ) deposition is one of the main hallmarks of Alzheimer’s disease. The
study assessed the associations between cortical and subcortical 11C-Pittsburgh Compound
B retention, namely in the hippocampus, ...
Differential involvement of the anterior temporal lobes in famous people semantics
(Frontiers media, 2016-08-30)
The ability to recognize a famous person occurs through semantic memory. Previous
neuroimaging studies have shown that the anterior temporal lobes (ATLs) are involved
in the recognition of famous people. However, it is ...
The role of the left anterior temporal lobe for unpredictable and complex mappings in word reading
(Frontiers media, 2017-04)
The anterior temporal lobes (ATLs) have been consistently associated with semantic
processing which, in turn, has a key role in reading aloud single words. This study aimed
to investigate (1) the reading abilities in ...
Comprehension of concrete and abstract words in patients with selective anterior temporal lobe resection and in patients with selective amygdalo-hippocampectomy
(Elsevier, 2012-01-08)
The role of the anterior temporal lobe (ATL) in semantic memory is now firmly established.
There is still controversy, however, regarding the specific role of this region in processing
various types of concepts. There ...
Naming unique entities in the semantic variant of primary progressive aphasia and Alzheimer's disease : Towards a better understanding of the semantic impairment
(Elsevier, 2016-12-07)
While the semantic variant of primary progressive aphasia (svPPA) is characterized by a predominant semantic memory impairment, episodic memory impairments are the clinical hallmark of Alzheimer's disease (AD). However, ...
Early-onset and late-onset Alzheimer’s disease are associated with distinct patterns of memory impairment
Memory impairment in EOAD and LOAD
(2016-01-01)
The goal of this study was to investigate the specific patterns of memory breakdown in patients suffering from early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD). Twenty EOAD patients, twenty ...
Neural changes associated with semantic processing in healthy aging despite intact behavioral performance
(2015-10-01)
Semantic memory recruits an extensive neural network including the left inferior
prefrontal cortex (IPC) and the left temporoparietal region, which are involved in
semantic control processes, as well as the anterior ...
Education as a moderator of the relationship between episodic memory and amyloid load in normal aging
(Oxford University Press, 2019-10-23)
The current study explored whether education, a proxy of cognitive reserve, modifies the
association between episodic memory (EM) performance and βeta-amyloid load (Aβ), a biomarker
of Alzheimer’s disease, in a cohort ...
Amyloid burden and white matter hyperintensities mediate age-related cognitive differences
(Elsevier, 2019-08)
This study examined the additive versus synergistic contribution of beta-amyloid (Aβ) and white matter hyperintensities (WMHs) across 7 cognitive domains in 104 cognitively normal older adults. It also measured the extent ...