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Postoperative administration of the acetylcholinesterase inhibitor, donepezil, interferes with bone healing and implant osseointegration in a rat model
(MDPI, 2020-09-14)
Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative ...
Dose-dependent pharmacokinetics of ropivacaine in anesthetized rabbits : absence of changes in protein binding
(Annex Publishers, 2019-04-25)
Objective: The primary objectives of this study were to investigate the in vivo pharmacokinetics and in vitro plasma protein binding of
ropivacaine at the concentration range observed after intravenous administration of ...
Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF
(Frontiers Media, 2020-11-25)
Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, ...
Modeling treatment effect modification in multidrug-resistant tuberculosis in an individual patient data meta-analysis
(SAGE, 2021)
Effect modification occurs while the effect of the treatment is not homogeneous across the different strata of patient characteristics. When the effect of treatment may vary from individual to individual, precision medicine ...
Universal cures for idiosyncratic illnesses: a genealogy of therapeutic reasoning in the mental health field
(SAGE Publications, 2014-08)
Over the past decades, there has been a significant increase in prescriptions of psychotropic drugs for mental disorders. So far, most of the explanations of the phenomenon have focused on the process of medicalization, ...
Coiled-coil affinity-based system for the controlled release of biofunctionalized gold nanoparticles from alginate hydrogels
(American Chemical Society, 2019-04-05)
Affinity-based systems represent a promising solution to control the delivery of therapeutics using hydrogels. Here, we report a hybrid system that is based on the peptidic E/K coiled coil affinity pair to mediate the ...
Nonspecific interactions in biomedical applications
(Elsevier, 2019-12-20)
Nonspecific interactions play a major role in the microscale functioning of biological units. Exploiting these interactions in design and application of biomedical systems has been beneficial in different branches of ...
Lubrication and wear protection of micro-structured hydrogels using bioinspired fluids
(American Chemical Society, 2018-11-21)
We report the fabrication and the use of a bioinspired synovial fluid acting as a lubricant fluid
and anti-wear agent at soft and porous chitosan hydrogel tribopairs. This synthetic synovial
fluid is composed of sodium ...
Subtle and unexpected role of PEG in tuning the penetration mechanisms of PLA-based nano-formulations into intact and impaired skin
(Elsevier, 2019-02-27)
We present a systematic study of the role of poly(ethylene glycol) (PEG) content in NPs on drug skin absorption. Cholecalciferol-loaded NPs of 100 nm of diameter were prepared by flash nanoprecipitation from PLA-b-PEG ...
Prescription channeling of COX-2 inhibitors and traditional nonselective nonsteroidal anti-inflammatory drugs: a population-based case–control study
(2005)
This pharmacoepidemiologic study was conducted to determine whether risk factors for upper gastrointestinal bleeding influenced the prescription of cyclo-oxygenase (COX)-2 inhibitors and traditional nonselective nonsteroidal ...