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Coiled-coil affinity-based system for the controlled release of biofunctionalized gold nanoparticles from alginate hydrogels
(American Chemical Society, 2019-04-05)
Affinity-based systems represent a promising solution to control the delivery of therapeutics using hydrogels. Here, we report a hybrid system that is based on the peptidic E/K coiled coil affinity pair to mediate the ...
Nonspecific interactions in biomedical applications
(Elsevier, 2019-12-20)
Nonspecific interactions play a major role in the microscale functioning of biological units. Exploiting these interactions in design and application of biomedical systems has been beneficial in different branches of ...
Lubrication and wear protection of micro-structured hydrogels using bioinspired fluids
(American Chemical Society, 2018-11-21)
We report the fabrication and the use of a bioinspired synovial fluid acting as a lubricant fluid
and anti-wear agent at soft and porous chitosan hydrogel tribopairs. This synthetic synovial
fluid is composed of sodium ...
Subtle and unexpected role of PEG in tuning the penetration mechanisms of PLA-based nano-formulations into intact and impaired skin
(Elsevier, 2019-02-27)
We present a systematic study of the role of poly(ethylene glycol) (PEG) content in NPs on drug skin absorption. Cholecalciferol-loaded NPs of 100 nm of diameter were prepared by flash nanoprecipitation from PLA-b-PEG ...
Unified scaling of the structure and loading of nanoparticles formed via diffusion-limited coalescence
(American Chemical Society, 2018-04-30)
The present study establishes the scaling laws describing the structure of spherical nanoparticles formed by diffusion-limited coalescence. We produced drug-loaded nanoparticles from a poly(ethylene glycol)-poly(d,l-lactic ...
Biomimetic bottle-brush polymer coatings for fabrication of ultra-low fouling surfaces
(Wiley, 2018-11-13)
The increasing demand for long lasting antifouling surfaces has steered the development of accessible, novel, biocompatible and environmentally-friendly materials. Inspired by lubricin (LUB), a component of mammalian ...
Chitosan hydrogel micro-bio-devices with complex capillary patterns via reactive-diffusive self-assembly
(Elsevier, 2019-08-29)
We present chitosan hydrogel microfluidic devices with self-assembled complex
microcapillary patterns, conveniently formed by a diffusion-reaction process.
These patterns in chitosan hydrogels are formed by a single-step ...
Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release
(American Chemical Society, 2018-01-29)
Doxorubicin (Dox) is a drug of choice in the design of drug delivery systems directed towards breast cancers, but is often limited by loading and control over its release from polymer micelles. Bile acid-based block ...
Non-covalent formulation of active principles with dendrimers: current state-of-the-art and prospects for further development
(Elsevier, 2017-09-06)
During the last three decades, dendrimers, nano-sized highly-branched fractal-like symmetrical macromolecules, have been intensively studied as promising candidates for application as drug-delivery carriers. Among other ...
Superlubricity of zwitterionic bottlebrush polymers in the presence of multivalent ions
(American Chemical Society, 2020-08-13)
In this study, we report lubrication properties of physisorbed zwitterionic bottlebrush polymers in the presence of
multivalent ions using the surface force apparatus. Unlike polyelectrolyte brushes, the lubrication ...