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Postoperative administration of the acetylcholinesterase inhibitor, donepezil, interferes with bone healing and implant osseointegration in a rat model
(MDPI, 2020-09-14)
Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative ...
Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF
(Frontiers Media, 2020-11-25)
Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, ...
Étude de l’effet des médicaments antiplaquettaires sur la fonction plaquettaire : de la variabilité de réponse à l’effet rebond
(2010-05-05)
En inhibant la formation de caillots dans le sang, les médicaments antiplaquettaires diminuent de façon importante le risque d’événements ischémiques aigus. Cependant, une sous-population de patients souffrant de maladie ...
The brain-derived neurotrophic factor prompts platelet aggregation and secretion
(American Society of Hematology, 2021-09-21)
Brain-derived neurotrophic factor (BDNF) has both autocrine and paracrine roles in
neurons, and its release and signaling mechanisms have been extensively studied in the
central nervous system. Large quantities of BDNF ...
Platelet quiescence in patients with acute coronary syndrome undergoing coronary artery bypass graft surgery
(Wiley, 2021)
BACKGROUND: The optimal antiplatelet strategy for patients with acute coronary syndromes who require coronary artery
bypass surgery remains unclear. While a more potent antiplatelet regimen will predispose to perioperative ...
Advances in platelet function testing—light transmission aggregometry and beyond
(MDPI, 2020-08-13)
Platelet function testing is essential for the diagnosis of hemostasis disorders. While there
are many methods used to test platelet function for research purposes, standardization is often
lacking, limiting their use ...
Tissue-specificity of antibodies raised against TrkB and p75NTR receptors ; implications for platelets as models of neurodegenerative diseases
(Frontiers media, 2021-02-11)
Platelets and neurons share many similarities including comparable secretory granule
types with homologous calcium-dependent secretory mechanisms as well as
internalization, sequestration and secretion of many ...
A meta-analysis of the effect of paper versus digital reading on reading comprehension in health professional education
(American Association of Colleges of Pharmacy, 2021-12-29)
Objective. Despite a rise in the use of digital education in health professional education (HPE), little is
known about the comparative effectiveness of paper-based reading and its digital alternative on reading
comprehension. ...
Acetylcholinesterase inhibitors and risk of bleeding and acute ischemic events in non-hypertensive Alzheimer’s patients
(2021-08-20)
Introduction: Acetylcholinesterase inhibitors (AChEIs) are commonly used to treat
mild to moderate cases of Alzheimer disease (AD). To the best of our knowledge, there
has been no study estimating the risk of bleeding ...