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Characterization of Endoproteolytic Processing of Dynorphins by Proprotein Convertases using Mouse Spinal Cord S9 Fractions and Mass Spectrometry
(2016-06-01)
Dynorphins are important neuropeptides with a central role in nociception and pain alleviation. Many mechanisms regulate endogenous dynorphin concentrations, including proteolysis. Proprotein convertases (PCs) are widely ...
Assessment of meat authenticity using bioinformatics, targeted peptide biomarkers and high-resolution mass spectrometry
(2015-10-01)
In recent years, we observed a significant increase of food fraud ranging from false label claims to the use of additives and fillers to increase profitability. Recently in 2013, horse and pig DNA were detected in beef ...
Impact of Actinobacillus pleuropneumoniae biofilm mode of growth on the lipid A structures and stimulation of immune cells
(2016-05-25)
Actinobacillus pleuropneumoniae (APP), the etiologic agent of porcine pleuropneumonia, forms biofilms on biotic and abiotic surfaces. APP biofilms confers resistance to antibiotics. To our knowledge, no studies have examined ...
Liquid Chromatography-Electrospray Linear Ion Trap Mass Spectrometry Analysis of Targeted Neuropeptides in Tac1-/- Mouse Spinal Cords Reveal Significant Lower Concentration of Opioid Peptides
(2015-08)
Tachykinin and opioid peptides play a central role in pain transmission, modulation and
inhibition. The treatment of pain is very important in medicine and many studies using NK1
receptor antagonists failed to show ...
Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions
(2015-11-01)
Substance P (SP) play a central role in nociceptive transmission and it is an agonist of the
Neurokinin-1 receptor located in the lamina I of the spinal cord. SP is a major proteolytic product
of the protachykinin-1 ...
Impaired EAT-4 vesicular glutamate transporter leads to defective nocifensive response of caenorhabditis elegans to noxious heat
(Springer, 2019-04-26)
In mammals, glutamate is an important excitatory neurotransmitter. Glutamate and
glutamate receptors are found in areas specifically involved in pain sensation, transmission
and transduction such as peripheral nervous ...
Capsaicin and Its analogues impede nocifensive response of caenorhabditis elegans to noxious heat
(2020-05-05)
Capsaicin is the most abundant pungent molecule identifed in red chili peppers, and it is widely used for food favoring,
in pepper spray for self-defense devices and recently in ointments for the relief of neuropathic ...
Post weaning diarrhea in pigs: risk factors and non‑colistin‑based control strategies
(2017)
Post-weaning diarrhea (PWD) is one of the most serious threats for the swine industry worldwide. It is commonly associated with the proliferation of enterotoxigenic Escherichia coli in the pig intestine. Colistin, a cationic ...
Resistance to colistin : what is the fate for this antibiotic in pig production?
(2016-08)
Colistin, a cationic polypeptide antibiotic, has reappeared in human medicine as a last-line treatment option for multidrug-resistant Gram-negative bacteria (MDR-GNB). Colistin is widely used in veterinary medicine for the ...
Actinobacillus pleuropneumoniae induces SJPL cell cycle arrest in G2/M-phase and inhibits porcine reproductive and respiratory syndrome virus replication
(2015-12)
Background: Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens
in the swine industry and causes important economic losses. No effective antiviral drugs against it are ...