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  Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment 

  Dubé, M.; Roy, B.B.; Guiot-Guillain, P.; Binette, J.; Mercier, J.; Chiasson, A.; Cohen, É.A. (2010)

  The Vpu accessory protein promotes HIV-1 release by counteracting Tetherin/BST-2, an interferon-regulated restriction factor, which retains virions at the cell-surface. Recent reports proposed beta-TrCP-dependent proteasomal ...
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  Pkd1 transgenic mice: Adult model of polycystic kidney disease with extrarenal and renal phenotypes 

  Kurbegovic, Almira; Côté, O.; Couillard, M.; Ward, C.J.; Harris, P.C.; Trudel, M. (2010)

  While high levels of Pkd1 expression are detected in tissues of patients with autosomal dominant polycystic kidney disease (ADPKD), it is unclear whether enhanced expression could be a pathogenetic mechanism for this ...
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  Computational prediction of neural progenitor cell fates 

  Cohen, A.R.; Gomes, F.L.A.F.; Roysam, B.; Cayouette, M. (2010)

  Understanding how stem and progenitor cells choose between alternative cell fates is a major challenge in developmental biology. Efforts to tackle this problem have been hampered by the scarcity of markers that can be used ...
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  HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest 

  Belzile, J.-P.; Richard, J.; Rougeau, N.; Xiao, Y.; Cohen, É.A. (2010)

  HIV-1 viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by a mechanism involving the activation of the DNA damage sensor ATR. We and others recently showed that Vpr performs this function by subverting ...
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  Development and disease of the photoreceptor cilium 

  Ramamurthy, V.; Cayouette, M. (2009)

  Primary cilia are microtubule-rich hair-like extensions protruding from the surface of most post-mitotic cells. They act as sensory organelles that help interpret various environmental cues. Mutations in genes encoding ...
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  HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing 

  Richard, J.; Sindhu, S.; Pham, T.N.Q; Belzile, J.-P.; Cohen, É.A. (2010)

  HIV upregulates cell-surface expression of specific ligands for the activating NKG2D receptor, including ULBP-1, -2, -3, but not MICA or MICB, in infected cells both in vitro and in vivo. However, the viral factor(s) ...
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  Effect of calcium-modulating cyclophilin ligand on human immunodeficiency virus type 1 particle release and cell surface expression of Tetherin 

  Bego, M.G.; Dubé, M.; Mercier, J.; Cohen, É.A. (2009)

  The HIV-1 accessory protein Vpu enhances virus particle release by counteracting a host factor that retains virions at the cell surface of infected cells. It was recently demonstrated that cellular protein BST2/CD317/Tetherin ...
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  The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: In vivo mouse model 

  Sun, X.; Essalmani, R.; Seidah, N. G.; Prat, A. (2009)

  The secretory basic amino acid-specific proprotein convertases (PCs) have often been associated with cancer/metastasis. By controlling the cleavage of cancer-associated proteins, PCs play key roles in multiple steps of ...

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