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Fac. Méd. - Institut de recherches cliniques de Montréal

Fac. Méd. - Institut de recherches cliniques de Montréal

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Fac. Méd. - Institut de recherches cliniques de Montréal - Publications [18]

Recent Submissions

Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment

Dubé, M.; Roy, B.B.; Guiot-Guillain, P.; Binette, J.; Mercier, J.; Chiasson, A.; Cohen, É.A. (2010)

The Vpu accessory protein promotes HIV-1 release by counteracting Tetherin/BST-2, an interferon-regulated restriction factor, which retains virions at the cell-surface. Recent reports proposed beta-TrCP-dependent proteasomal ...
Pkd1 transgenic mice: Adult model of polycystic kidney disease with extrarenal and renal phenotypes

Kurbegovic, A.; Côté, O.; Couillard, M.; Ward, C.J.; Harris, P.C.; Trudel, M. (2010)

While high levels of Pkd1 expression are detected in tissues of patients with autosomal dominant polycystic kidney disease (ADPKD), it is unclear whether enhanced expression could be a pathogenetic mechanism for this ...
Computational prediction of neural progenitor cell fates

Cohen, A.R.; Gomes, F.L.A.F.; Roysam, B.; Cayouette, M. (2010)

Understanding how stem and progenitor cells choose between alternative cell fates is a major challenge in developmental biology. Efforts to tackle this problem have been hampered by the scarcity of markers that can be used ...
HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest

Belzile, J.-P.; Richard, J.; Rougeau, N.; Xiao, Y.; Cohen, É.A. (2010)

HIV-1 viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by a mechanism involving the activation of the DNA damage sensor ATR. We and others recently showed that Vpr performs this function by subverting ...
Development and disease of the photoreceptor cilium

Ramamurthy, V.; Cayouette, M. (2009)

Primary cilia are microtubule-rich hair-like extensions protruding from the surface of most post-mitotic cells. They act as sensory organelles that help interpret various environmental cues. Mutations in genes encoding ...