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Interleukin-8 predicts fatigue at 12 months post-injury in children with traumatic brain injury

dc.contributor.authorCrichton, Alison
dc.contributor.authorIgnjatovic, Vera
dc.contributor.authorBabl, Franz E.
dc.contributor.authorOakley, Ed
dc.contributor.authorGreenham, Mardee
dc.contributor.authorHearps, Stephen
dc.contributor.authorDelzoppo, Carmel
dc.contributor.authorBeauchamp, Miriam
dc.contributor.authorGuerguerian, Anne‐Marie
dc.contributor.authorBoutis, Kathy
dc.contributor.authorHubara, Evyatar
dc.publisherMary Ann Liebertfr
dc.subjectSerum biomarkersfr
dc.subjectGlasgow coma scalefr
dc.subjectTraumatic brain injuryfr
dc.titleInterleukin-8 predicts fatigue at 12 months post-injury in children with traumatic brain injuryfr
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. Département de psychologiefr
dcterms.abstractDespite many children experiencing fatigue after childhood brain injury, little is known about the predictors of this complaint. To date, traditional indices of traumatic brain injury (TBI) severity have not reliably predicted persisting fatigue (up to 3 years post‐injury). This study aimed to establish if persisting fatigue is predicted by serum biomarker concentrations in child TBI. We examined if acute serum biomarker expression would improve prediction models of 12‐month fatigue based on injury severity. Blood samples were collected from 87 children (1 – 17 years at injury) sustaining mild to severe TBI (GCS range 3‐15; mean 12.43; classified as mild TBI (n=50, 57%) vs moderate/severe TBI n=37, 43%), and presenting to the Emergency Departments (ED) and Pediatric Intensive Care Units (PICU) at one of three tertiary pediatric hospitals (Royal Children’s Hospital (RCH); Hospital for Sick Children (HSC), Toronto St Justine Children’s Hospital (SJH), Montreal). Six serum biomarker concentrations were measured within 24 hours of injury [interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), soluble vascular cell adhesion molecule (SVCAM), S100 calcium binding protein B (S100B), neuron specific enolase (NSE), and soluble neural cell adhesion molecule (sNCAM)]. Fatigue at 12 months post‐injury was measured using the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (parent report), classified as present/absent using previously derived cut‐points. At 12 months post‐injury, 22% of participants experienced fatigue. A model including interleukin‐8 (IL‐8) was the best serum biomarker for estimating the probability of children experiencing fatigue at 12 months post‐injury. IL‐8 also significantly improved predictive models of fatigue based on
dcterms.alternativeInterleukin‐8 predict fatigue in child TBIfr
UdeM.ReferenceFournieParDeposantCrichton, A. J., Ignjatovic, V., Babl, F., Oakley, E., Greenham, M., Hearps, S. J., ... & Hubara, E. H. (2019). Interleukin-8 Predicts Fatigue at 12 Months Post-injury in Children with Traumatic Brain Injury. Journal of Neurotrauma, (ja).fr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr
oaire.citationTitleJournal of neurotrauma

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