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dc.contributor.authorIsmaylova, Elmira
dc.contributor.authorLévesque, Melissa
dc.contributor.authorPomares, Florence B.
dc.contributor.authorSzyf, Moshe
dc.contributor.authorNemoda, Zsofia
dc.contributor.authorFahim, Cherine
dc.contributor.authorVitaro, Frank
dc.contributor.authorBrendgen, Mara
dc.contributor.authorDionne, Ginette
dc.contributor.authorBoivin, Michel
dc.contributor.authorTremblay, Richard Ernest
dc.contributor.authorBooij, Linda
dc.date.accessioned2020-05-05T16:39:17Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2020-05-05T16:39:17Z
dc.date.issued2018-08-08
dc.identifier.urihttp://hdl.handle.net/1866/23331
dc.publisherSpringer Naturefr
dc.rightsCe document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDepressionfr
dc.subjectHuman behaviourfr
dc.titleSerotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli : a study of adolescent monozygotic twinsfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. École de psychoéducationfr
dc.identifier.doi10.1038/s41398-018-0195-6
dcterms.abstractSeveral studies have examined associations between peripheral DNA methylation patterns of the serotonin transporter gene (SLC6A4) promoter and symptoms of depression and anxiety. The SLC6A4 promoter methylation has also been associated with frontal-limbic brain responses to negative stimuli. However, it is unclear how much of this association is confounded by DNA sequence variations. We utilized a monozygotic-twin within-pair discordance design, to test whether DNA methylation at specific CpG sites in the SLC6A4 promoter of peripheral cells is associated with greater frontal-limbic brain responses to negative stimuli (sadness and fear), independently of DNA sequence effects. In total 48 pairs of healthy 15-year-old monozygotic twins from the Quebec Newborn Twin Study, followed regularly since birth, underwent functional magnetic resonance imaging while conducting an emotion-processing task. The SLC6A4 promoter methylation level was assessed in saliva samples using pyrosequencing. Relative to the co-twins with lower SLC6A4 promoter methylation levels, twins with higher peripheral SLC6A4 methylation levels showed greater orbitofrontal cortical (OFC) activity and left amygdala-anterior cingulate cortex (ACC) and left amygdala-right OFC connectivity in response to sadness as well as greater ACC-left amygdala and ACC-left insula connectivity in response to fearful stimuli. By utilising a monozygotic-twin design, we provided evidence that associations between peripheral SLC6A4 promoter methylation and frontal-limbic brain responses to negative stimuli are, in part, independent of DNA sequence variations. Although causality cannot be determined here, SLC6A4 promoter methylation may be one of the mechanisms underlying how environmental factors influence the serotonin system, potentially affecting emotional processing through frontal-limbic areas.fr
dcterms.isPartOfurn:ISSN:2158-3188fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantIsmaylova, E., Lévesque, M. L., Pomares, F. B., Szyf, M., Nemoda, Z., Fahim, C., ... & Booij,L. (2018). Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins. Translational psychiatry, 8(1), 1-9.fr
UdeM.VersionRioxxVersion publiée / Version of Recordfr
oaire.citationTitleTranslational psychiatry
oaire.citationVolume8
oaire.citationIssue1


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Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.
RightsCe document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.