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dc.contributor.authorBémeur, Chantal
dc.contributor.authorCudalbu, Cristina
dc.contributor.authorDam, Gitte
dc.contributor.authorThrane, Alexander S.
dc.contributor.authorCooper, Arthur J. L.
dc.contributor.authorRose, Christopher
dc.subjectBrain edemafr
dc.subjectHepatic encephalopathyfr
dc.subjectMagnetic resonance imagingfr
dc.titleBrain edema : a valid endpoint for measuring hepatic encephalopathy?fr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine. Département de médecinefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine. Département de nutritionfr
dcterms.abstractHepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition impairment, attention deficits and motor dysfunction which eventually can progress to coma and death. Pathologically, HE is characterized by swelling of the astrocytes which consequently leads to brain edema, a common feature found in patients with acute liver failure (ALF) as well as in cirrhotic patients suffering from HE. The pathogenic factors involved in the onset of astrocyte swelling and brain edema in HE are unresolved. However, the role of astrocyte swelling/brain edema in the development of HE remains ambiguous and therefore measuring brain edema as an endpoint to evaluate HE is questioned. The following review will determine the effect of astrocyte swelling and brain edema on neurological function, discuss the various possible techniques to measure brain edema and lastly to propose a number of neurobehavioral tests to evaluate
UdeM.ReferenceFournieParDeposantBémeur, C., Cudalbu, C., Dam, G., Thrane, A. S., Cooper, A. J. L., & Rose, C. F. (2016). Brain edema: A valid endpoint for measuring hepatic encephalopathy? Metabolic Brain Disease, 31(6), 12491258.
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr
oaire.citationTitleMetabolic brain disease

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