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Subcortical amyloid load is associated with shape and volume in cognitively normal individuals

dc.contributor.authorRahayel, Shady
dc.contributor.authorBocti, Christian
dc.contributor.authorSévigny Dupont, Pénélope
dc.contributor.authorJoannette, Maude
dc.contributor.authorLavallée, Marie Maxime
dc.contributor.authorNikelski, Jim
dc.contributor.authorChertkow, Howard
dc.contributor.authorJoubert, Sven
dc.date.accessioned2019-06-04T12:43:33Z
dc.date.availableMONTHS_WITHHELD:12fr
dc.date.available2019-06-04T12:43:33Z
dc.date.issued2019-05-21
dc.identifier.urihttp://hdl.handle.net/1866/22115
dc.publisherWileyfr
dc.subjectAlzheimer’s diseasefr
dc.subjectAmyloid-betafr
dc.subjectSubcorticalfr
dc.subjectVolumefr
dc.subjectShapefr
dc.titleSubcortical amyloid load is associated with shape and volume in cognitively normal individualsfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. Département de psychologiefr
dc.identifier.doi10.1002/hbm.24680
dcterms.abstractAmyloid-beta (Aβ) deposition is one of the main hallmarks of Alzheimer’s disease. The study assessed the associations between cortical and subcortical 11C-Pittsburgh Compound B retention, namely in the hippocampus, amygdala, putamen, caudate, pallidum, and thalamus, and subcortical morphology in cognitively normal individuals. We recruited 104 cognitive normal individuals who underwent extensive neuropsychological assessment, PiB-positron emission tomography (PET) scan and 3-tesla magnetic resonance imaging (MRI) acquisition of T1-weighted images. Global, cortical, and subcortical regional PiB retention values were derived from each scan and subcortical morphology analyses were performed to investigate vertex-wise local surface and global volumes, including the hippocampal subfields volumes. We found that subcortical regional Aβ was associated with the surface of the hippocampus, thalamus, and pallidum, with changes being due to volume and shape. Hippocampal Aβ was marginally associated with volume of the whole hippocampus as well as with the CA1 subfield, subiculum, and molecular layer. Participants showing higher subcortical Aβ also showed worse cognitive performance and smaller hippocampal volumes. In contrast, global and cortical PiB uptake did not associate with any subcortical metrics. This study shows that subcortical Aβ is associated with subcortical surface morphology in cognitively normal individuals. This study highlights the importance of quantifying subcortical regional PiB retention values in these individuals.fr
dcterms.alternativeSubcortical Aβ associates to morphometryfr
dcterms.bibliographicCitationHuman brain mappingfr
dcterms.isPartOfurn:ISSN:1065-9471fr
dcterms.isPartOfurn:ISSN:1097-0193fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantdoi: 10.1002/hbm.24680 PMID: 31148327fr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr


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