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dc.contributor.authorToro, Roberto
dc.contributor.authorPoline, Jean-Baptiste
dc.contributor.authorConrod, Patricia
dc.contributor.authorImagen Consortium
dc.date.accessioned2018-09-25T12:25:47Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2018-09-25T12:25:47Z
dc.date.issued2015-08
dc.identifier.urihttp://hdl.handle.net/1866/20928
dc.publisherNature Publishing Groupfr
dc.subjectNeuroanatomyfr
dc.subjectHeritabilityfr
dc.subjectNeuroimagingfr
dc.subjectGeneticsfr
dc.titleGenomic architecture of human neuroanatomical diversityfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine. Département de psychiatriefr
dc.identifier.doi10.1101/001198
dcterms.abstractHuman brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for <5% of the variance. Here, based on our analyses of neuroimaging and whole-genome genotyping data from 1765 subjects, we show that up to 54% of this heritability is captured by large numbers of single-nucleotide polymorphisms of small-effect spread throughout the genome, especially within genes and close regulatory regions. The genetic bases of neuroanatomical diversity appear to be relatively independent of those of body size (height), but shared with those of verbal intelligence scores. The study of this genomic architecture should help us better understand brain evolution and disease.fr
dcterms.isPartOfurn:ISSN:1359-4184fr
dcterms.isPartOfurn:ISSN:1476-5578fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantToro, R., Poline, J. B., ..., Conrod, P., ... & IMAGEN Consortium. (2015 ) Genomic architecture of human neuroanatomical diversity. Molecular Psychiatry, 20(8), 1011-1016.fr
UdeM.VersionRioxxVersion originale de l'auteur / Author's Originalfr
oaire.citationTitleMolecular psychiatry
oaire.citationVolume20
oaire.citationIssue8
oaire.citationStartPage1011
oaire.citationEndPage1016


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