Effects of delaying binge drinking on adolescent brain development : a longitudinal neuroimaging study
dc.contributor.author | Bourque, Josiane | |
dc.contributor.author | Baker, Travis E. | |
dc.contributor.author | Dagher, Alain | |
dc.contributor.author | Evans, Alan C. | |
dc.contributor.author | Garavan, Hugh | |
dc.contributor.author | Leyton, Marco | |
dc.contributor.author | Séguin, Jean | |
dc.contributor.author | Pihl, Robert | |
dc.contributor.author | Conrod, Patricia | |
dc.date.accessioned | 2018-09-13T13:39:47Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2018-09-13T13:39:47Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://hdl.handle.net/1866/20875 | |
dc.publisher | BMC | fr |
dc.subject | Neurodevelopment | fr |
dc.subject | Alcohol use | fr |
dc.subject | Adolescence | fr |
dc.subject | Preventative intervention program | fr |
dc.subject | Functional imaging | fr |
dc.title | Effects of delaying binge drinking on adolescent brain development : a longitudinal neuroimaging study | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de psychiatrie et d'addictologie | fr |
dc.identifier.doi | 10.1186/s12888-016-1148-3 | |
dcterms.abstract | Background: Onset of alcohol use by 14 relative to 21 years of age strongly predicts elevated risk for severe alcohol use problems, with 27% versus 4% of individuals exhibiting alcohol dependence within 10 years of onset. What remains unclear is whether this early alcohol use (i) is a marker for later problems, reflected as a pre-existing developmental predisposition, (ii) causes global neural atrophy or (iii) specifically disturbs neuro-maturational processes implicated in addiction, such as executive functions or reward processing. Since our group has demonstrated that a novel intervention program targeting personality traits associated with adolescent alcohol use can prevent the uptake of drinking and binge drinking by 40 to 60%, a crucial question is whether prevention of early onset alcohol misuse will protect adolescent neurodevelopment and which domains of neurodevelopment can be protected. Methods: A subsample of 120 youth at high risk for substance misuse and 30 low-risk youth will be recruited from the Co-Venture trial (Montreal, Canada) to take part in this 5-year follow-up neuroimaging study. The Co-Venture trial is a community-based cluster-randomised trial evaluating the effectiveness of school-based personality-targeted interventions on substance use and cognitive outcomes involving approximately 3800 Grade 7 youths. Half of the 120 high-risk participants will have received the preventative intervention program. Cognitive tasks and structural and functional neuroimaging scans will be conducted at baseline, and at 24- and 48-month follow-up. Two functional paradigms will be used: the Stop-Signal Task to measure motor inhibitory control and a modified version of the Monetary Incentive Delay Task to evaluate reward processing. Discussion: The expected results should help identify biological vulnerability factors, and quantify the consequences of early alcohol abuse as well as the benefits of early intervention using brain metrics. | fr |
dcterms.isPartOf | urn:ISSN:1471-244X | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | Bourque, J., Baker, T., Dagher, A., Evans, A. C., Garavan, H., Leyton, M., Séguin, J. R., Pihl, R. O. & Conrod, P. (2016) Effects of delaying binge drinking on adolescent brain development: a longitudinal neuroimaging study. BMC Psychiatry, 445, 1-9. | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | BMC psychiatry | |
oaire.citationVolume | 16 |
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