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dc.contributor.authorFerraz-Pereira, Kelli N.
dc.contributor.authorDa Silva Aragão, Raquel
dc.contributor.authorVerdier, Dorly
dc.contributor.authorToscano, Ana E.
dc.contributor.authorLacerda, Diego C.
dc.contributor.authorManhães-de-Castro, Raul
dc.contributor.authorKolta, Arlette
dc.date.accessioned2018-01-19T16:49:24Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2018-01-19T16:49:24Z
dc.date.issued2015-09
dc.identifier.citationFerraz-Pereira KN, da Silva Aragão R, Verdier D, Toscano AE, Lacerda DC, Manhães-de-Castro R, Kolta A. Neonatal low-protein diet reduces the masticatory efficiency in rats. Br J Nutr. 2015 Nov 14;114(9):1515-30. doi: 10.1017/S0007114515003062. Epub 2015 Sep 4. PubMed PMID: 26337745fr
dc.identifier.urihttp://hdl.handle.net/1866/19740
dc.subjectAP action potentialfr
dc.subjectGABA γ-aminobutyric acidfr
dc.subjectINaP sodium persistent currentfr
dc.subjectMasseter musclefr
dc.subjectMasticatory efficiencyfr
dc.subjectN nourishedfr
dc.subjectNMDA N-methyl-d-aspartatefr
dc.subjectNVsnpr trigeminal main sensory nucleusfr
dc.subjectRB regular burstsfr
dc.subjectTrigeminal nucleusfr
dc.subjectU undernourishedfr
dc.subjectUndernutritionfr
dc.titleNeonatal low-protein diet reduces the masticatory efficiency in ratsfr
dc.typeArticlefr
dc.contributor.affiliationFaculté de médecine dentairefr
UdeM.statutProfesseur(e) / Professorfr
dc.identifier.doi10.1017/S0007114515003062
dcterms.abstractLittle is known about the effects of undernutrition on the specific muscles and neuronal circuits involved in mastication. The aim of this study was to document the effects of neonatal low-protein diet on masticatory efficiency. Newborn rats whose mothers were fed 17 % (nourished (N), n 60) or 8% (undernourished (U), n 56) protein were compared. Their weight was monitored and their masticatory jaw movements were video-recorded. Whole-cell patch-clamp recordings were performed in brainstem slice preparations to investigate the intrinsic membrane properties and N-methyl-Daspartate- induced bursting characteristics of the rhythmogenic neurons (N, n 43; U, n 39) within the trigeminal main sensory nucleus (NVsnpr). Morphometric analysis (N, n 4; U, n 5) were conducted on masseteric muscles serial cross-sections. Our results showed that undernourished animals had lower numbers of masticatory sequences (P=0·049) and cycles (P=0·045) and slower chewing frequencies (P=0·004) (N, n 32; U, n 28). Undernutrition reduced body weight but had little effect on many basic NVsnpr neuronal electrophysiological parameters. It did, however, affect sag potentials (P<0·001) and rebound firing (P=0·005) that influence firing pattern. Undernutrition delayed the appearance of bursting and reduced the propensity to burst (P=0·002), as well as the bursting frequency (P=0·032). Undernourished animals showed increased and reduced proportions of fibre type IIA (P<0·0001) and IIB (P<0·0001), respectively. In addition, their fibre areas (IIA, P<0·001; IIB, P<0·001) and perimeters (IIA, P<0·001; IIB, P<0·001) were smaller. The changes observed at the behavioural, neuronal and muscular levels suggest that undernutrition reduces chewing efficiency by slowing, weakening and delaying maturation of the masticatory muscles and the associated neuronal circuitry.fr
dcterms.bibliographicCitationBritish Journal of Nutrition;Vol. 114, no 9
dcterms.isPartOfurn:ISSN:1475-2662
dcterms.isPartOfurn:ISSN:0007-1145
dcterms.languageengfr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscript


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