Now showing items 1-5 of 5

  • Amyloid burden and white matter hyperintensities mediate age-related cognitive differences 

    Sévigny Dupont, Pénélope; Bocti, Christian; Joannette, Maude; Lavallée, Marie Maxime; Nikelski, Jim; Vallet, Guillaume; Chertkow, Howard; Joubert, Sven (Elsevier, 2019-08)
    This study examined the additive versus synergistic contribution of beta-amyloid (Aβ) and white matter hyperintensities (WMHs) across 7 cognitive domains in 104 cognitively normal older adults. It also measured the extent to which age-related differences ...
  • Education as a moderator of the relationship between episodic memory and amyloid load in normal aging 

    Joannette, Maude; Bocti, Christian; Sévigny Dupont, Pénélope; Lavallée, Marie Maxime; Nikelski, Jim; Vallet, Guillaume; Chertkow, Howard; Joubert, Sven (Oxford University Press, 2019-10-23)
    The current study explored whether education, a proxy of cognitive reserve, modifies the association between episodic memory (EM) performance and βeta-amyloid load (Aβ), a biomarker of Alzheimer’s disease, in a cohort of cognitively normal older ...
  • A qualitative impairment in face perception in Alzheimer’s disease : evidence from a reduced face inversion effect 

    face inversion effect in Alzheimer’s disease
    Lavallée, Marie Maxime; Gandini, Delphine; Rouleau, Isabelle; Vallet, Guillaume; Joannette, Maude; Kergoat, Marie-Jeanne; Busigny, Thomas; Rossion, Bruno; Joubert, Sven (2016-04-12)
    Prevalent face recognition difficulties in Alzheimer’s disease (AD) have typically been attributed to the underlying episodic and semantic memory impairment. The aim of the current study was to determine if AD patients are also impaired at the perceptual ...
  • Subcortical amyloid load is associated with shape and volume in cognitively normal individuals 

    Subcortical Aβ associates to morphometry
    Rahayel, Shady; Bocti, Christian; Sévigny Dupont, Pénélope; Joannette, Maude; Lavallée, Marie Maxime; Nikelski, Jim; Chertkow, Howard; Joubert, Sven (Wiley, 2019-05-21)
    Amyloid-beta (Aβ) deposition is one of the main hallmarks of Alzheimer’s disease. The study assessed the associations between cortical and subcortical 11C-Pittsburgh Compound B retention, namely in the hippocampus, amygdala, putamen, caudate, pallidum, ...
  • Subcortical amyloid relates to cortical morphology in cognitively normal individuals 

    Rahayel, Shady; Bocti, Christian; Sévigny Dupont, Pénélope; Joannette, Maude; Lavallée, Marie Maxime; Nikelski, Jim; Chertkow, Howard; Joubert, Sven (Springer, 2019-07-25)
    Purpose Amyloid (Aβ) brain deposition can occur in cognitively normal individuals and is associated with cortical volume abnormalities. Aβ-related volume changes are inconsistent across studies. Since volume is composed of surface area and thickness, ...