Browsing Faculté de pharmacie – Travaux et publications by Subject "Platelets"

Now showing items 1-5 of 5

  • Advances in platelet function testing—light transmission aggregometry and beyond 

    Le Blanc, Jessica; Mullier, François; Vayne, Caroline; Lordkipanidzé, Marie (MDPI, 2020-08-13)
    Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light ...

  • Antiplatelet therapy for atherothrombotic disease in 2022 : from population to patient-centered approaches 

    Jourdi, Georges; Godier, Anne; Lordkipanidzé, Marie; Marquis-Gravel, Guillaume; Gaussem, Pascale (Frontiers Media, 2022-01-28)
    Antiplatelet agents, with aspirin and P2Y12 receptor antagonists as major key molecules, are currently the cornerstone of pharmacological treatment of atherothrombotic events including a variety of cardio- and cerebro-vascular as well as peripheral ...

  • Brain-derived neurotrophic factor mitigates the association between platelet dysfunction and cognitive impairment 

    Bélanger, Jean-Christophe; Bouchard, Véronique; Le Blanc, Jessica; Starnino, Louisia; Welman, Mélanie; Chabot-Blanchet, Malorie; Busseuil, David; Chertkow, Howard; D'Antono, Bianca; Lordkipanidzé, Marie (Frontiers media, 2021-09-07)
    Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), ...

  • Current and novel antiplatelet therapies for the treatment of cardiovascular diseases 

    Jourdi, Georges; Lordkipanidzé, Marie; Philippe, Aurélien; Bachelot-Loza, Christilla; Gaussem, Pascale (MDPI, 2021-12-03)
    Over the last decades, antiplatelet agents, mainly aspirin and P2Y12 receptor antagonists, have significantly reduced morbidity and mortality associated with arterial thrombosis. Their pharmacological characteristics, including pharmacokinetic/pharmacodynamics ...

  • Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF 

    Le Blanc, Jessica; Fleury, Samuel; Boukhatem, Imane; Bélanger, Jean‐Christophe; Welman, Mélanie; Lordkipanidzé, Marie (Frontiers Media, 2020-11-25)
    Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, it has been suggested that ...