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dc.contributor.authorFravalo, Philippe
dc.contributor.authorTamazight, Cherifi
dc.contributor.authorNeira Feliciano, Kersti Dina
dc.contributor.authorLetellier, Ann
dc.contributor.authorFairbrother, Julie-Hélène
dc.contributor.authorBekal, Sadjia
dc.titleCharacterisation of InlA truncation in Listeria monocytogenes isolates from farm animals and human cases in the province of Quebecfr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine vétérinairefr
UdeM.statutProfesseur(e) / Professorfr
dcterms.abstractThe introduction of Listeria monocytogenes into the food production chain is a concern, with numerous grouped cases of listeriosis associated with milk-derived or pork-derived products have been documented. Management of this zoonotic pathogen considers all strains as an equal risk. Recently, a new perspective for characterisation of strain virulence was introduced with the discovery of the unaltered sequence of InlA as a determinant of strain virulence; this has also been reported as an infrequent finding among so-called environmental strains, that is, strains isolated from food or from surfaces in food industries. The aim of this study was to differentiate L monocytogenes strains isolated from animal cases versus those from human cases and to differentiate clinical strains from environmental ones using a Caenorhabditis elegans virulence testing model. In Quebec in 2013/2014, the surveillance of L monocytogenes clinical isolates registered a total of 20 strains of animal origin and 16 pulsed-field gel electrophoresis types isolated from human cases. The mixed PCR multiplex agglutination protocol used for geno-serotyping clearly discriminated genogroup IVB strains from bovine and human origins. The presence of a premature stop codon single nucleotide polymorphism in the inlA gene sequence in clinical strains and the identical behaviour of particular strains in the C elegans model are discussed in this paper from the perspective of industrial management of L monocytogenes
UdeM.VersionRioxxVersion originale de l'auteur·e / Author's Original
oaire.citationTitleVeterinary record open

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