Faculté de médecine
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Reconstruction of phase maps from the configuration of phase singularities in two-dimensional manifolds
(American Physical Society, 2012-05-24)Phase singularity analysis provides a quantitative description of spiral wave patterns observed in chemical or biological excitable media. The configuration of phase singularities (locations and directions of rotation) is easily derived from phase ... -
Modeling atrial arrhythmias : impact on clinical diagnosis and therapies
(Institute of electrical and electronics engineers, 2008)Atrial arrhythmias are the most frequent sustained rhythm disorders in humans and often lead to severe complications such as heart failure and stroke. Despite the important insights provided by animal models into the mechanisms of atrial arrhythmias, ... -
Evaluation of a subject-specific transfer-function-based nonlinear QT interval rate-correction method
(IOP Publishing, 2011-04-15)The QT interval in the electrocardiogram (ECG) is a measure of total duration of depolarization and repolarization. Correction for heart rate is necessary to provide a single intrinsic physiological value that can be compared between subjects and within ... -
An eikonal approach for the initiation of reentrant cardiac propagation in reaction-diffusion models
(Institute of electrical and electronics engineers, 2010-05-27)Microscale electrical propagation in the heart can be modeled by a reaction-diffusion system describing cell and tissue electrophysiology. Macroscale features of wavefront propagation can be reproduced by an eikonal model, a reduced formulation involving ... -
Extraction and analysis of T waves in electrocardiograms during atrial flutter
(Institute of electrical and electronics engineers, 2010-12-13)Analysis of T waves in the electrocardiogram (ECG) is an essential clinical tool for diagnosis, monitoring and followup of patients with heart dysfunction. During atrial flutter, this analysis has been so far limited by the perturbation of flutter waves ... -
Eikonal-based initiation of fibrillatory activity in thin-walled cardiac propagation models
(American Institute of Physics, 2011-12-22)Reentrant arrhythmias can be simulated in electrophysiological models of electrical impulse propagation governed by a reaction-diffusion system. To facilitate the initiation of a large number of independent episodes of simulated arrhythmias with ... -
Equivalent dipole sources to estimate the influence of extracellular myocardial anisotropy in thin-walled cardiac forward models
(Elsevier, 2017)The extracellular domain of the heart is anisotropic, which affects volume conduction and therefore body surface potentials. This paper tests the hypothesis that when wall thickness is sufficiently small (such as in the atria), the effect of extracellular ... -
Assessment of the sensitivity of detecting drug-induced QTc changes using subject-specific rate correction
(Elsevier, 2012)Aims To quantify the sensitivity of QT heart-rate correction methods for detecting drug-induced QTc changes in thorough QT studies. Methods Twenty-four-hour Holter ECGs were analyzed in 66 normal subjects during placebo and moxifloxacin delivery ... -
A simple analytical model of action potential duration profile in electrotonically-coupled cells
(Elsevier, 2016)Electrotonic interactions between cardiac cells modulate the dispersion of action potential duration (APD). This paper provides a complete mathematical analysis of a simple model of exponential-shaped repolarization in a network of electrotonically-coupled ... -
QT interval measurement and correction in patients with atrial flutter : a pilot study
(Elsevier, 2014)Background and Purpose Measurement of QT intervals during atrial flutter (AFL) is relevant to monitor the safety of drug delivery. Our aim is to compare QT and QTc intervals in AFL patients before and after catheter ablation in order to validate QT ...