RSS 1.0Faculté de médecine
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A numerical scheme for modeling wavefront propagation on a monolayer of arbitrary geometry
(Institute of electrical and electronics engineers, 2003-04-15)The majority of models of wavefront propagation in cardiac tissue have assumed relatively simple geometries. Extensions to complicated three-dimensional (3-D) representations are computationally challenging due to issues related both to problem size ... -
Pacemaker activity resulting from the coupling with nonexcitable cells
(American Physical Society, 2006-07-14)Fibroblasts are nonexcitable cells that are sometimes coupled with excitable cells (cardiomyocytes). Due to a higher resting potential, these cells may act as a current source or sink and therefore disturb the electrical activity of the surrounding ... -
The effect of tissue geometry on the activation recovery interval of atrial myocytes
(Elsevier, 2008-08-13)The propagation of electric activity inside a realistically-shaped, thick-walled model of the atria was studied. The membrane kinetics was based on the formulations of Courtemanche, Ramirez and Nattel. In spite of the assumed uniformity of all ... -
Steady-state solutions in mathematical models of atrial cell electrophysiology and their stability
(Elsevier, 2006-11-10)The steady states of the Fenton–Karma, the Courtemanche and the Nygren cell models were studied by determining the fixed points of the dynamical system describing their cell kinetics. The linear stability of the fixed points was investigated, as well ... -
Analysis of electrocardiograms during atrial fibrillation
(Institute of electrical and electronics engineers, 2006-11-30)The research discussed in this article is motivated by the search for an optimal classification of the different types of atrial fibrillation (AF) on the basis of recorded atrial signals. This would facilitate the selection of an optimal therapy. This ... -
Reconstruction of phase maps from the configuration of phase singularities in two-dimensional manifolds
(American Physical Society, 2012-05-24)Phase singularity analysis provides a quantitative description of spiral wave patterns observed in chemical or biological excitable media. The configuration of phase singularities (locations and directions of rotation) is easily derived from phase ... -
Modeling atrial arrhythmias : impact on clinical diagnosis and therapies
(Institute of electrical and electronics engineers, 2008)Atrial arrhythmias are the most frequent sustained rhythm disorders in humans and often lead to severe complications such as heart failure and stroke. Despite the important insights provided by animal models into the mechanisms of atrial arrhythmias, ... -
Evaluation of a subject-specific transfer-function-based nonlinear QT interval rate-correction method
(IOP Publishing, 2011-04-15)The QT interval in the electrocardiogram (ECG) is a measure of total duration of depolarization and repolarization. Correction for heart rate is necessary to provide a single intrinsic physiological value that can be compared between subjects and within ... -
An eikonal approach for the initiation of reentrant cardiac propagation in reaction-diffusion models
(Institute of electrical and electronics engineers, 2010-05-27)Microscale electrical propagation in the heart can be modeled by a reaction-diffusion system describing cell and tissue electrophysiology. Macroscale features of wavefront propagation can be reproduced by an eikonal model, a reduced formulation involving ... -
Extraction and analysis of T waves in electrocardiograms during atrial flutter
(Institute of electrical and electronics engineers, 2010-12-13)Analysis of T waves in the electrocardiogram (ECG) is an essential clinical tool for diagnosis, monitoring and followup of patients with heart dysfunction. During atrial flutter, this analysis has been so far limited by the perturbation of flutter waves ...
