Now showing items 1-10 of 3671

  • Paternal age explains a major portion of de novo germline mutation rate variability in healthy individuals 

    Girard, Simon L.; Bourassa, Cynthia V.; Lemieux Perreault, Louis-Philippe; Legault, Marc-André; Barhdadi, Amina; Ambalavanan, Amirthagowri; Brendgen, Mara; Vitaro, Frank; Noreau, Anne; Dionne, Ginette; Tremblay, Richard Ernest; Dion, Patrick A.; Boivin, Michel; Dubé, Marie-Pierre; Rouleau, Guy (Public Library of Science, 2016-10-10)
    De novo mutations (DNM) are an important source of rare variants and are increasingly being linked to the development of many diseases. Recently, the paternal age effect has been the focus of a number of studies that attempt to explain the observation ...
  • Gestational age at birth and ‘Body-Mind’ health at 5 years of age : a population based cohort study 

    Cronin, Frances M.; Segurado, Ricardo; McAuliffe, Fionnuala M.; Kelleher, Cecily C.; Tremblay, Richard Ernest (Public Library of Science, 2016-03-14)
    Numerous studies have identified the effects of prematurity on the neonate’s physical health, however few studies have explored the effects of prematurity on both the physical and mental health of the child as they develop. Secondary analysis of data ...
  • Associations of prenatal urinary bisphenol a concentrations with child behaviors and cognitive abilities 

    Braun, Joseph M.; Muckle, Gina; Arbuckle, Tye; Bouchard, Maryse F.; Fraser, William; Ouellet, Emmanuel; Séguin, Jean; Oulhote, Youssef; Webster, Glenys M.; Lanphear, Bruce P. (National Institute of Environmental Health Sciences, 2017)
    BACKGROUND: Prenatal bisphenol A (BPA) exposure has been associated with adverse neurodevelopment in epidemiological studies. However, prior studies had limited statistical power to examine sex-specific effects, and few examined child cognition. ...
  • Effects of delaying binge drinking on adolescent brain development : a longitudinal neuroimaging study 

    Bourque, Josiane; Baker, Travis E.; Dagher, Alain; Evans, Alan C.; Garavan, Hugh; Leyton, Marco; Séguin, Jean; Pihl, Robert; Conrod, Patricia (BMC, 2016)
    Background: Onset of alcohol use by 14 relative to 21 years of age strongly predicts elevated risk for severe alcohol use problems, with 27% versus 4% of individuals exhibiting alcohol dependence within 10 years of onset. What remains unclear is ...
  • Victimization, suicidal ideation, and alcohol use from age 13 to 15 years : support for the Self-Medication Model 

    Marschall-Lévesque, Shawn; Castellanos Ryan, Natalie; Parent, Sophie; Renaud, Johanne; Vitaro, Frank; Boivin, Michel; Tremblay, Richard Ernest; Séguin, Jean (Elsevier, 2017-04)
    Purpose—Recent years have seen increased coverage of adolescent victimization and suicide. Both adolescent peer victimization and substance use have been associated with suicidal ideation, with evidence suggesting that all three factors are interrelated. ...
  • 3D Cohort Study : The Integrated Research Network in Perinatology of Quebec and Eastern Ontario 

    Fraser, William; Shapiro, Gabriel; Dubois, Lise; Pasquier, Jean-Charles; Julien, Pierre; Berard, Anick; Muckle, Gina; Trasler, Jacquetta; Tremblay, Richard Ernest; Abenhaim, Haim; Welt, Michel; Bissonnette, François; Bédard, Marie-Josée; Bujold, Emmanuel; Gagnon, Robert; Michaud, Jacques; Girard, Isabelle; Moutquin, Jean-Marie; Marc, Isabelle; Monnier, Patricia; Luo, Zhong-Cheng; 3D Study Group; Séguin, Jean; Audibert, François (Wiley, 2016)
    Background: The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children. Methods: Pregnant ...
  • Intrinsic motivation and achievement in mathematics in elementary school : a longitudinal investigation of their association 

    Motivation and mathematical achievement
    Garon‐Carrier, Gabrielle; Boivin, Michel; Guay, Frédéric; Kovas, Yulia; Dionne, Ginette; Lemelin, Jean‐Pascal; Séguin, Jean; Vitaro, Frank; Tremblay, Richard Ernest (Wiley, 2015-11)
    This study examined the associations between intrinsic motivation and achievement in mathematics in a sample of 1,478 Canadian school‐age children followed from Grades 1 to 4 (ages 7–10). Children self‐reported their intrinsic motivation toward ...
  • Differential susceptibility to environmental influences : Interactions between child temperament and parenting in adolescent alcohol use 

    Rioux, Charlie; Castellanos Ryan, Natalie; Parent, Sophie; Vitaro, Frank; Tremblay, Richard Ernest; Séguin, Jean (Cambridge University Press, 2016-02)
    Temperament and parental practices (PP) are important predictors of adolescent alcohol use (AU); however, less is known about how they combine to increase or decrease risk of AU. This study examined whether age 6 temperament (i.e., impulsivity and ...
  • BDNF Val66Met polymorphism interacts with sleep consolidation to predict ability to create new declarative memories 

    Gosselin, Nadia; De Beaumont, Louis; Gagnon, Katia; Baril, Andrée-Ann; Mongrain, Valérie; Blais, Hélène; Montplaisir, Jacques-Yves; Gagnon, Jean-François; Pelleieux, Sandra; Poirier, Judes; Carrier, Julie (Society for Neuroscience, 2016-08)
    It is hypothesized that a fundamental function of sleep is to restore an individual's day-to-day ability to learn and to constantly adapt to a changing environment through brain plasticity. Brain-derived neurotrophic factor (BDNF) is among the key ...
  • Early cannabis use, polygenic risk score for schizophrenia and brain maturation in adolescence 

    French, Leon; Gray, Courtney; Leonard, Gabriel; Perron, Michel; Pike, Bruce; Richer, Louis; Séguin, Jean; Veillette, Suzanne; Evans, John; Artiges, Eric; Banaschewski, Tobias; Bokde, Arun W. L.; Bromberg, Uli; Bruehl, Ruediger; Buchel, Christian; Cattrell, Anna; Conrod, Patricia; Flor, Herta; Frouin, Vincent; Gallinat, Jurgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Lemaitre, Herve; Martinot, Jean-Luc; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Pangelinan, Melissa Marie; Poustka, Luise; Rietschel, Marcella; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Timpson, Nic J.; Schumann, Gunter; Smith, George Davey; Smith, George Davey; Pausova, Zdenka; Paus, Tomáš (American Medical Association, 2015-10)
    IMPORTANCE: Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain ...