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Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects
(2002-12)
Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals ...
Hypothermia in acute liver failure
(2004)
The development of encephalopathy in patients with acute liver injury defines the occurrence of liver failure. The encephalopathy of acute liver failure is characterized by brain edema which manifests clinically as increased ...
Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis
(2003)
Induction of cyclooxygenase-2 (COX-2) has been described in a wide range of neurological diseases including animal models of epilepsy. The present study was undertaken to assess COX-2 expression in hippocampal biopsies ...
Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis
(2006)
OBJECTIVE: Acute liver failure (ALF) is haemodynamically characterized by a hyperdynamic circulation. The aims of this study were to investigate the systemic and regional haemodynamics in ALF, to measure changes in nitric ...
Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia
(2004)
The principal cause of mortality in patients with acute liver failure (ALF) is brain herniation resulting from intracranial hypertension caused by a progressive increase of brain water. In the present study, ex vivo ...
Contractile response of femoral arteries in pigs with acute liver failure
(2004)
BACKGROUND: Acute liver failure (ALF) is characterized haemodynamically by a progressive hyperdynamic circulation. The pathophysiological mechanism is unknown, but impaired contractility of vascular smooth muscle may play ...
Keeping cool in acute liver failure: rationale for the use of mild hypothermia
(2005)
Encephalopathy, brain edema and intracranial hypertension are neurological complications responsible for substantial morbidity/mortality in patients with acute liver failure (ALF), where, aside from liver transplantation, ...
Increased expression of "peripheral-type" benzodiazepine receptors in human temporal lobe epilepsy: implications for PET imaging of hippocampal sclerosis
(2002)
Increased binding sites for "peripheral-type" benzodiazepine receptor (PTBR) ligands have been described in a wide range of neurological disorders including both human and experimental epilepsy. This study was undertaken ...
Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release?
(2002)
Glutamatergic dysfunction has been suggested to play an important role in the pathogenesis of hepatic encephalopathy (HE) in acute liver failure (ALF). Increased extracellular brain glutamate concentrations have consistently ...
Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study
(2006-01)
BACKGROUND: Increased intracranial pressure (ICP) worsens the outcome of acute liver failure (ALF). This study investigates the underlying pathophysiological mechanisms and evaluates the therapeutic effect of albumin ...