Now showing items 1-5 of 5
L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action
Strategies aimed at the lowering of blood ammonia remain the treatment of choice in portal-systemic encephalopathy (PSE). L-ornithine-L-aspartate (OA) has recently been shown to be effective in the prevention of ...
Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure
It has been suggested that reduced astrocytic uptake of neuronally released glutamate contributes to the pathogenesis of hepatic encephalopathy in acute liver failure. In order to further address this issue, the recently ...
Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle
The effects of chronic liver insufficiency resulting from end-to-side portacaval anastomosis (PCA) on glutamine synthetase (GS) activities, protein and gene expression were studied in brain, liver and skeletal muscle of ...
Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction
BACKGROUND & AIMS: Manganese (Mn) deposition could be responsible for the T(1)-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional ...
Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure
There is increasing evidence that central noradrenaline (NA) transport mechanisms are implicated in the central nervous system complications of acute liver failure. In order to assess this possibility, binding sites for ...