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Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure

Chatauret, Nicolas; Desjardins, Paul; Zwingmann, Claudia; Rose, Christopher F.; Rao, Rama K. V.; Butterworth, Roger F. (2006-06)

BACKGROUND/AIMS: It has been proposed that, in acute liver failure, skeletal muscle adapts to become the principle organ responsible for removal of blood-borne ammonia by increasing glutamine synthesis, a reaction that is ...