Now showing items 1-20 of 73

  • A 12-week open-label, multicenter study evaluating the safety and patient-reported efficacy of sodium oxybate in patients with narcolepsy and cataplexy 

    Mamelak, Mortimer; Swick, Todd; Emsellem, Helene; Montplaisir, Jacques-Yves; Lai, Chinglin; Black, Jed (Elsevier, 2015)
    Objective: This study aimed to evaluate safety and efficacy of sodium oxybate (SXB) titrated to effect. Methods: SXB-naive patients who had participated in a randomized SXB clinical trial and had not been titrated to adequate clinical effect were ...
  • 3D Cohort Study : The Integrated Research Network in Perinatology of Quebec and Eastern Ontario 

    Fraser, William; Shapiro, Gabriel; Dubois, Lise; Pasquier, Jean-Charles; Julien, Pierre; Bérard, Anick; Muckle, Gina; Trasler, Jacquetta; Tremblay, Richard Ernest; Abenhaim, Haim; Welt, Michel; Bissonnette, François; Bédard, Marie-Josée; Bujold, Emmanuel; Gagnon, Robert; Michaud, Jacques; Girard, Isabelle; Moutquin, Jean-Marie; Marc, Isabelle; Monnier, Patricia; Luo, Zhong-Cheng; 3D Study Group; Séguin, Jean; Audibert, François (Wiley, 2016)
    Background: The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children. Methods: Pregnant ...
  • Analysis of common and rare VPS13C variants in late-onset Parkinson disease 

    Rudakou, Uladzislau; Ruskey, Jennifer A.; Krohn, Lynne; Laurent, Sandra B.; Spiegelman, Dan; Greenbaum, Lior; Yahalom, Gilad; Desautels, Alex; Montplaisir, Jacques-Yves; Fahn, Stanley; Waters, Cheryl; Levy, Oren; Kehoe, Caitlin M.; Narayan, Sushma; Dauvilliers, Yves; Dupré, Nicolas; Hassin-Baer, Sharon; Alcalay, Roy N.; Rouleau, Guy; Fon, Edward A.; Gan-Or, Ziv (Lippincott, Williams and Wilkins, 2020-01-09)
    Objective We aimed to study the role of coding VPS13C variants in a large cohort of patients with lateonset Parkinson disease (PD) (LOPD). Methods VPS13C and its untranslated regions were sequenced using targeted next-generation sequencing in 1,567 ...
  • Association of protein phosphatase PPM1G with alcohol use disorder and brain activity during behavioral control in a genome-wide methylation analysis 

    Ruggeri, Barbara; Nymberg, Charlotte; Vuoksimaa, Eero; Conrod, Patricia; Imagen Consortium (American Psychiatric Publishing, 2015-06)
    OBJECTIVE: The genetic component of alcohol use disorder is substantial, but monozygotic twin discordance indicates a role for nonheritable differences that could be mediated by epigenetics. Despite growing evidence associating epigenetics and ...
  • Associations of prenatal urinary bisphenol a concentrations with child behaviors and cognitive abilities 

    Braun, Joseph M.; Muckle, Gina; Arbuckle, Tye; Bouchard, Maryse F.; Fraser, William; Ouellet, Emmanuel; Séguin, Jean; Oulhote, Youssef; Webster, Glenys M.; Lanphear, Bruce P. (National Institute of Environmental Health Sciences, 2017)
    BACKGROUND: Prenatal bisphenol A (BPA) exposure has been associated with adverse neurodevelopment in epidemiological studies. However, prior studies had limited statistical power to examine sex-specific effects, and few examined child cognition. ...
  • BDNF Val66Met polymorphism interacts with sleep consolidation to predict ability to create new declarative memories 

    Gosselin, Nadia; De Beaumont, Louis; Gagnon, Katia; Baril, Andrée-Ann; Mongrain, Valérie; Blais, Hélène; Montplaisir, Jacques-Yves; Gagnon, Jean-François; Pelleieux, Sandra; Poirier, Judes; Carrier, Julie (Society for Neuroscience, 2016-08)
    It is hypothesized that a fundamental function of sleep is to restore an individual's day-to-day ability to learn and to constantly adapt to a changing environment through brain plasticity. Brain-derived neurotrophic factor (BDNF) is among the key ...
  • Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents 

    Büchel, Christian; Peters, Jan; Banaschewski, Tobias; Bokde, Arun W. L.; Bromberg, Uli; Conrod, Patricia; Flor, Herta; Papadopoulos Orfanos, Dimitri; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Walter, Henrik; Ittermann, Bernd; Mann, Karl; Martinot, Jean-Luc; Paillère-Martinot, Marie-Laure; Nees, Frauke; Paus, Tomáš; Pausova, Zdenka; Poustka, Luise; Rietschel, Marcella; Robbins, Trevor W.; Smolka, Michael N.; Gallinat, Jürgen; Schumann, Gunter; Knutson, Brian; Imagen Consortium (Nature Research, 2017-02-21)
    Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability ...
  • Cannabis use in early adolescence: evidence of amygdala hypersensitivity to signals of threat 

    Spechler, Philip A.; Orr, Catherine A.; Chaarani, Bader; Conrod, Patricia; Bromberg, Uli; Imagen Consortium (Elsevier, 2015-12)
    Cannabis use in adolescence may be characterized by differences in the neural basis of affective processing. In this study, we used an fMRI affective face processing task to compare a large group (n = 70) of 14-year olds with a history of cannabis use ...
  • Children’s cortisol response to the transition from preschool to formal schooling : a review 

    Parent, Sophie; Lupien, Sonia; Herba, Catherine; Dupéré, Véronique; Gunnar, Megan R.; Séguin, Jean (Elsevier, 2018-09-14)
    This review examines the current state of knowledge regarding children's biological stress response during the transition from preschool to compulsory formal schooling, focusing on longitudinal studies that include repeated measures of cortisol ...
  • Co-morbidity between gambling problems and depressive symptoms: A longitudinal perspective of risk and protective factors 

    Dussault, Frédéric; Brendgen, Mara; Vitaro, Frank; Carbonneau, René; Boivin, Michel; Tremblay, Richard Ernest (Springer Verlag, 2016)
    In both adolescents and adults, gambling problems and depressive symptoms co-occur and share some common risk factors (e.g., impulsivity and socio-family risk). However, little is known about (1) the developmental course of the co-morbidity of these ...
  • Common genetic variants influence human subcortical brain structures 

    Hibar, Derrek P.; Stein, Jason L.; Renteria, Miguel E.; Arias-Vasquez, Alejandro; Desrivières, Sylvane; Jahanshad, Neda (Nature Research, 2015-04-09)
    The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal ...
  • Comorbid development of disruptive behaviors from age 1½ to 5 years in a population birth-cohort and association with school adjustment in first grade 

    Comorbidity of Disruptive Behaviors from age 1½ to 5 years
    Carbonneau, René; Boivin, Michel; Brendgen, Mara; Nagin, Daniel; Tremblay, Richard Ernest (Springer Verlag, 2016-05)
    Comorbidity is frequent among disruptive behaviors (DB) and leads to mental health problems during adolescence and adulthood. However, the early developmental origins of this comorbidity have so far received little attention. This study investigated ...
  • The content of recurrent dreams in young adolescents 

    Gauchat, Aline; Séguin, Jean; McSween-Cadieux, Esther; Zadra, Antonio (Elsevier, 2015-12)
    Studies on children’s recurrent dreams have been largely anecdotal and based on adults’ recollections of dreams experienced during childhood. We collected 102 reports of recurrent dreams from a sample of young adolescents aged between 11 and 15 ...
  • Correlated gene expression supports synchronous activity in brain networks 

    Richiardi, Jonas; Altmann, Andre; Milazzo, Anna-Clare; Chang, Catie; Conrod, Patricia; Imagen Consortium (American Association for the Advancement of Science, 2015-06-12)
    During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional ...
  • Correlation of changes in patient-reported quality of life with physician-rated global impression of change in patients with narcolepsy participating in a clinical trial of sodium oxybate : a post hoc analysis 

    Bogan, Richard; Black, Jed; Swick, Todd; Mamelak, Mortimer; Kovacevic-Ristanovic, Ruzica; Villa, Kathleen F.; Mori, Fannie; Montplaisir, Jacques-Yves (Springer, 2017-07-13)
    Introduction: Narcolepsy patients report lower health-related quality of life (HRQoL) than the general population, as measured by the Short Form-36 Health Survey (SF-36). This analysis evaluated whether changes in SF-36 correlated with physician-rated ...
  • The dementia-associated APOE ε4 allele is not associated with REM sleep behavior disorder 

    Gan-Or, Ziv; Montplaisir, Jacques-Yves; Ross, Jay P.; Poirier, Judes; Warby, Simon; Arnulf, Isabelle; Strong, Stephanie; Dauvilliers, Yves; Leblond, Claire S.; Hu, Michele T. M.; Högl, Birgit; Stefani, Ambra; Monaca, Christelle; Cochen De Cock, Valérie; Boivin, Michel; Ferini-Strambi, Luigi; Plazzi, Giuseppe; Antelmi, Elena; Young, Peter; Heidbreder, Anna; Barber, Thomas R; Evetts, Samuel G.; Rolinski, Michal; Dion, Patrick A.; Desautels, Alex; Gagnon, Jean-François; Dupré, Nicolas; Postuma, Ronald B.; Rouleau, Guy (Elsevier, 2016-10-13)
    The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). ...
  • Developmental associations between conduct problems and expressive language in early childhood : a population-based study 

    Conduct problems and language
    Girard, Lisa-Christine; Pingault, Jean-Baptiste; Doyle, Orla; Falissard, Bruno; Tremblay, Richard Ernest (Springer, 2016-08)
    Conduct problems have been associated with poor language development, however the direction of this association in early childhood remains unclear. This study examined the longitudinal directional associations between conduct problems and expressive ...
  • Developmental origins of chronic physical aggression: an international perspective on using singletons, twins and epigenetics 

    Tremblay, Richard Ernest (SAGE, 2015-09-08)
    This chapter takes an international and historical perspective to discuss the present state of knowledge on the developmental origins of physical aggression and its implications for the prevention of chronic physical aggression. An increasing number ...
  • Dietary intake at 9 years and subsequent body mass index in adolescent boys and girls: a study of monozygotic twin pairs 

    Diet and weight status in adolescent twins
    Dubois, Lise; Diasparra, Maikol; Bogl, Leonie-Helen; Fontaine-Bisson, Bénédicte; Bédard, Brigitte; Tremblay, Richard Ernest; Kaprio, Jaakko; Boivin, Michel (Cambridge University Press, 2016-02)
    There is a lack of evidence pointing to specific dietary elements related to weight gain and obesity prevention in childhood and adulthood. Dietary intake and obesity are both inherited and culturally transmitted, but most prospective studies on the ...
  • Differential susceptibility to environmental influences : Interactions between child temperament and parenting in adolescent alcohol use 

    Rioux, Charlie; Castellanos Ryan, Natalie; Parent, Sophie; Vitaro, Frank; Tremblay, Richard Ernest; Séguin, Jean (Cambridge University Press, 2016-02)
    Temperament and parental practices (PP) are important predictors of adolescent alcohol use (AU); however, less is known about how they combine to increase or decrease risk of AU. This study examined whether age 6 temperament (i.e., impulsivity and ...