Prorenin/renin receptor blockade promotes a healthy fat distribution in obese mice
dc.contributor.author | Tan, Paul | |
dc.contributor.author | Blais, Carolane | |
dc.contributor.author | Nguyen, Thi M.-D. | |
dc.contributor.author | Schiller, Peter W. | |
dc.contributor.author | Lavoie, Julie | |
dc.date.accessioned | 2024-07-15T12:38:41Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2024-07-15T12:38:41Z | |
dc.date.issued | 2016-09 | |
dc.identifier.uri | http://hdl.handle.net/1866/33557 | |
dc.publisher | Wiley | fr |
dc.title | Prorenin/renin receptor blockade promotes a healthy fat distribution in obese mice | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. École de kinésiologie et des sciences de l'activité physique | fr |
dc.identifier.doi | 10.1002/oby.21592 | |
dcterms.abstract | ObjectiveAdministration of the handle region peptide (HRP), a (pro)renin receptor blocker, decreases body weight gain and visceral adipose tissue (VAT) in high-fat/high-carbohydrate (HF/HC) diet-fed mice. The objective of this study was to elucidate potential mechanisms implicated in these observations.MethodsMice were given a normal or a HF/HC diet along with saline or HRP for 10 weeks.ResultsIn HF/HC-fed mice, HRP increased the expression of several enzymes implicated in lipogenesis and lipolysis in subcutaneous fat (SCF) while the expression of the enzyme implicated in the last step of lipogenesis decreased in VAT. A reduction was also observed in circulating free fatty acids in these animals which was accompanied by normalized adipocyte size in VAT and increased adipocyte size in SCF. ''Beiging'' is the evolution of a white adipose tissue toward a brown-like phenotype characterized by an increased mitochondrial density and small lipid droplets. HRP increased the expression of' “beiging” markers in SCF of HF/HC diet-fed mice.ConclusionsHRP treatment may favor healthy fat storage in SCF by activating a triglyceride/free fatty acid cycling and “beiging,” which could explain the body weight and fat mass reduction. | fr |
dcterms.isPartOf | urn:ISSN:1930-7381 | fr |
dcterms.isPartOf | urn:ISSN:1930-739X | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | Voir avec LC 10.1002/oby.21592 | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | fr |
oaire.citationTitle | Obesity | fr |
oaire.citationVolume | 24 | fr |
oaire.citationIssue | 9 | fr |
oaire.citationStartPage | 1823 | fr |
oaire.citationEndPage | 2012 | fr |
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