Association of genetic variants with body-mass index and blood pressure in adolescents : a replication study
Article [Version of Record]
Abstract(s)
The strong correlation between adiposity and blood pressure (BP) might be explained in
part by shared genetic risk factors. A recent study identified three nucleotide variants
[rs16933812 (PAX5), rs7638110 (MRPS22), and rs9930333 (FTO)] associated with both
body mass index (BMI) and systolic blood pressure (SBP) in adolescents age 12–18years.
We attempted to replicate these findings in a sample of adolescents of similar age. A total
of 713 adolescents were genotyped and had anthropometric indicators and blood pressure
measured at age 13, 15, 17, and 24years. Using linear mixed models, we assessed
associations of these variants with BMI and SBP. In our data, rs9930333 (FTO) was
associated with body mass index, but not systolic blood pressure. Neither rs16933812
(PAX5) nor rs7638110 (MRPS22) were associated with body mass index or systolic blood
pressure. Although, differences in phenotypic definitions and in genetic architecture across
populations may explain some of the discrepancy across studies, nucleotide variant
selection in the initial study may have led to false-positive results that could not be replicated.