dc.contributor.author | Al-Hamed, Faez Saleh | |
dc.contributor.author | Abu-Nada, Lina | |
dc.contributor.author | Rodan, Rania | |
dc.contributor.author | Sarrigiannidis, Stylianos | |
dc.contributor.author | Ramirez-Garcialuna, Jose Luis | |
dc.contributor.author | Moussa, Hanan | |
dc.contributor.author | Elkashty, Osama A. | |
dc.contributor.author | Gao, Qiman | |
dc.contributor.author | Basir, Tayebeh | |
dc.contributor.author | Baca, Laura | |
dc.contributor.author | Torres, Jesus | |
dc.contributor.author | Rancan, Lisa | |
dc.contributor.author | Tran, Simon D. | |
dc.contributor.author | Lordkipanidzé, Marie | |
dc.contributor.author | Kaartinen, Mari | |
dc.contributor.author | Badran, Zahi | |
dc.contributor.author | Tamimi, Faleh | |
dc.date.accessioned | 2022-01-19T15:27:28Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2022-01-19T15:27:28Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://hdl.handle.net/1866/25963 | |
dc.publisher | Wiley | fr |
dc.rights | Ce document est mis à disposition selon les termes de la Licence Creative Commons Attribution - Pas d’utilisation commerciale 4.0 International. / This work is licensed under a Creative Commons Attribution - NonCommercial 4.0 International License. | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.subject | Bone formation | fr |
dc.subject | Bone healing | fr |
dc.subject | Critical size defect | fr |
dc.subject | Platelet concentrates | fr |
dc.subject | Platelet-rich plasma | fr |
dc.subject | Rat surgery | fr |
dc.title | Differences in platelet-rich plasma composition influence bone healing | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de pharmacie | fr |
dc.identifier.doi | 10.1111/jcpe.13546 | |
dcterms.abstract | Aim: Platelet-rich plasma (PRP) is an autologous blood-derived material that has been
used to enhance bone regeneration. Clinical studies, however, reported inconsistent
outcomes. This study aimed to assess the effect of changes in leucocyte and PRP
(L-PRP) composition on bone defect healing.
Materials and Methods: L-PRPs were prepared using different centrifugation
methods and their regenerative potential was assessed in an in-vivo rat model. Bilateral critical-size tibial bone defects were created and filled with single-spin L-PRP,
double-spin L-PRP, or filtered L-PRP. Empty defects and defects treated with collagen scaffolds served as controls. Rats were euthanized after 2 weeks, and their tibias
were collected and analysed using micro-CT and histology.
Results: Double-spin L-PRP contained higher concentrations of platelets than singlespin L-PRP and filtered L-PRP. Filtration of single-spin L-PRP resulted in lower concentrations of minerals and metabolites. In vivo, double-spin L-PRP improved bone healing by significantly reducing the size of bone defects (1.08 ± 0.2 mm3
) compared
to single-spin L-PRP (1.42 ± 0.27 mm3
) or filtered L-PRP (1.38 ± 0.28 mm3
). There
were fewer mast cells, lymphocytes, and macrophages in defects treated with
double-spin L-PRP than in those treated with single-spin or filtered L-PRP.
Conclusion: The preparation method of L-PRP affects their composition and potential to regenerate bone. | fr |
dcterms.isPartOf | urn:ISSN:0303-6979 | fr |
dcterms.isPartOf | urn:ISSN:1600-051X | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | PMID: 34517437 | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | Journal of clinical periodontology | fr |
oaire.citationVolume | 48 | fr |
oaire.citationStartPage | 1613 | fr |
oaire.citationEndPage | 1623 | fr |