dc.contributor.author | Perez-Contreras, Ana | |
dc.contributor.author | Barboza-Solis, Catalina | |
dc.contributor.author | Najimudeen, Shahnas M. | |
dc.contributor.author | Checkley, Sylvia | |
dc.contributor.author | Van der Meer, Frank | |
dc.contributor.author | Joseph, Tomy | |
dc.contributor.author | King, Robin | |
dc.contributor.author | Ravi, Madhu | |
dc.contributor.author | Peters, Delores | |
dc.contributor.author | Fonseca, Kevin | |
dc.contributor.author | Gagnon, Carl A. | |
dc.contributor.author | Ojkic, Davor | |
dc.contributor.author | Abdul-Careem, Mohamed Faizal | |
dc.date.accessioned | 2021-05-06T12:16:51Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2021-05-06T12:16:51Z | |
dc.date.issued | 2021-03-24 | |
dc.identifier.uri | http://hdl.handle.net/1866/24982 | |
dc.publisher | MDPI | fr |
dc.rights | Ce document est mis à disposition selon les termes de la Licence Creative Commons
Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0
International License. | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/deed.fr | |
dc.subject | Infectious laryngotracheitis virus | fr |
dc.subject | Pathogenicity | fr |
dc.subject | Transmission | fr |
dc.subject | Poultry | fr |
dc.subject | Vaccine revertant infectious laryngotracheitis virus | fr |
dc.title | Pathogenic and transmission potential of wildtype and
chicken embryo origin (CEO) vaccine revertant infectious laryngotracheitis virus | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine vétérinaire | fr |
dc.identifier.doi | 10.3390/v13040541 | |
dcterms.abstract | Infectious laryngotracheitis (ILT) is an infectious upper respiratory tract disease that
impacts the poultry industry worldwide. ILT is caused by an alphaherpesvirus commonly referred
to as infectious laryngotracheitis virus (ILTV). Vaccination with live attenuated vaccines is practiced
regularly for the control of ILT. However, extensive and improper use of live attenuated vaccines
is related to vaccine viruses reverting to virulence. An increase in mortality and pathogenicity has
been attributed to these vaccine revertant viruses. Recent studies characterized Canadian ILTV
strains originating from ILT outbreaks as related to live attenuated vaccine virus revertants. However,
information is scarce on the pathogenicity and transmission potential of these Canadian isolates.
Hence, in this study, the pathogenicity and transmission potential of two wildtype ILTVs and a
chicken embryo origin (CEO) vaccine revertant ILTV of Canadian origin were evaluated. To this
end, 3-week-old specific pathogen-free chickens were experimentally infected with each of the ILTV
isolates and compared to uninfected controls. Additionally, naïve chickens were exposed to the
experimentally infected chickens to mimic naturally occurring infection. Pathogenicity of each of
these ILTV isolates was evaluated by the severity of clinical signs, weight loss, mortality, and lesions
observed at the necropsy. The transmission potential was evaluated by quantification of ILTV genome
loads in oropharyngeal and cloacal swabs and tissue samples of the experimentally infected and
contact-exposed chickens, as well as in the capacity to produce ILT in contact-exposed chickens.
We observed that the CEO vaccine revertant ILTV isolate induced severe disease in comparison
to the two wildtype ILTV isolates used in this study. According to ILTV genome load data, CEO
vaccine revertant ILTV isolate was successfully transmitted to naïve contact-exposed chickens in
comparison to the tested wildtype ILTV isolates. Overall, the Canadian origin CEO vaccine revertant
ILTV isolate possesses higher virulence, and dissemination potential, when compared to the wildtype
ILTV isolates used in this study. These findings have serious implications in ILT control in chickens. | fr |
dcterms.isPartOf | urn:ISSN:1999-4915 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | Perez-Contreras A, Barboza-Solis C, Najimudeen SM, Checkley S, Meer FV, Joseph T, King R, Ravi M, Peters D, Fonseca K, Gagnon CA, Ojkic D, Abdul-Careem MF. Pathogenic and Transmission Potential of Wildtype and Chicken Embryo Origin (CEO) Vaccine Revertant Infectious Laryngotracheitis Virus. Viruses. 2021 Mar 24;13(4):541. doi: 10.3390/v13040541. PMID: 33805117; PMCID: PMC8064098. | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | Viruses | fr |
oaire.citationVolume | 13 | fr |
oaire.citationIssue | 4 | fr |