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dc.contributor.authorLeclercq, Loïc
dc.contributor.authorTessier, Jérémie
dc.contributor.authorNardello-Rataj, Véronique
dc.contributor.authorSchmitzer, Andreea-Ruxandra
dc.date.accessioned2021-03-25T12:15:53Z
dc.date.availableMONTHS_WITHHELD:12fr
dc.date.available2021-03-25T12:15:53Z
dc.date.issued2021-03-18
dc.identifier.urihttp://hdl.handle.net/1866/24938
dc.publisherWileyfr
dc.subjectBiobased formulationfr
dc.subjectPickering emulsionfr
dc.subjectAntimicrobialfr
dc.subjectAntibiofilmfr
dc.titleHighly active, entirely biobased antimicrobial Pickering emulsionsfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. Département de chimiefr
dc.identifier.doi10.1002/cmdc.202100030
dcterms.abstractWe present the development of surfactant‐free, silica‐free and fully biobased oil‐in‐water antimicrobial Pickering emulsions, based on the self‐assembly of b ‐cyclodextrin and phytoantimicrobial oils (terpinen‐4‐ol or carvacrol). Undecylenic acid (UA), derived from castor oil, can be used as bio‐based drug to treat fungal infection, but is less effective than petroleum‐based drugs as azole derivatives. To maximize its antifungal potential, we have incorporated UA in fully biobased Pickering emulsions. These emulsions are effective against fungi, Gram‐positive and Gram‐negative bacteria. The carvacrol emulsion charged with UA is +390 % and +165 % more potent against methicillin‐resistant S. aureus (MRSA), compared to UA and azole‐based commercial formulations. Moreover, this emulsion is up to +480 % more efficient that UA ointment against C. albicans . Finally, remarkable eradication of E. coli and MRSA biofilms was obtained with this environmental‐friendly emulsion.fr
dcterms.isPartOfurn:ISSN:1860-7179fr
dcterms.isPartOfurn:ISSN:1860-7187fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantChemMedChem cmdc.202100030R1 Highly active, entirely biobased antimicrobial Pickering emulsionsfr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr
oaire.citationTitleChemMedChemfr


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