Evaluation of quality of life in patients with narcolepsy treated with sodium oxybate : use of the 36-item short-form health survey in a clinical trial
dc.contributor.author | Bogan, Richard | |
dc.contributor.author | Swick, Todd | |
dc.contributor.author | Mamelak, Mortimer | |
dc.contributor.author | Kovacevic-Ristanovic, Ruzica | |
dc.contributor.author | Lai, Chinglin | |
dc.contributor.author | Black, Jed | |
dc.contributor.author | Villa, Kathleen F. | |
dc.contributor.author | Montplaisir, Jacques-Yves | |
dc.date.accessioned | 2020-06-09T15:56:37Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2020-06-09T15:56:37Z | |
dc.date.issued | 2016-10-24 | |
dc.identifier.uri | http://hdl.handle.net/1866/23449 | |
dc.publisher | Springer | fr |
dc.subject | Narcolepsy | fr |
dc.subject | Sodium oxybate | fr |
dc.subject | Quality of life | fr |
dc.subject | SF-36 | fr |
dc.title | Evaluation of quality of life in patients with narcolepsy treated with sodium oxybate : use of the 36-item short-form health survey in a clinical trial | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de psychiatrie et d'addictologie | fr |
dc.identifier.doi | 10.1007/s40120-016-0053-5 | |
dcterms.abstract | Introduction The present post hoc analysis was designed to evaluate health-related quality of life (HRQoL) using the 36-item Short Form Health Status Survey (SF-36) during an 8-week trial of sodium oxybate (SXB). Methods SF-36 was assessed in a phase 3 placebo-controlled trial in patients with narcolepsy (N = 228) randomized to placebo or SXB in doses of 4.5, 6, or 9 g nightly for 8 weeks. Changes from baseline in SF-36 (last observation carried forward) were compared between SXB and placebo, and effect sizes (ES) were estimated. Results Baseline SF-36 values were lower than normative values for the US general population. After 8 weeks of treatment, mean (±standard deviation) improvement from baseline on the Physical Component Summary (PCS) was significantly greater with SXB 9 g/night than placebo (6.3 ± 9.1 vs. 1.5 ± 6.2; p = 0.005), with moderate ES; no significant difference was found between the SXB and placebo groups on the Mental Component Summary. SXB 9 g/night resulted in significantly (p < 0.05) greater improvements than placebo in Physical Functioning (4.4 ± 9.2 vs. 1.0 ± 8.0), General Health (GH; 3.1 ± 7.0 vs. 0.4 ± 6.8), and Social Functioning (6.8 ± 16.8 vs. 1.1 ± 9.6). All SXB doses resulted in significant improvement (p < 0.05) relative to placebo for Vitality, with moderate ES. No significant differences versus placebo were observed for Role–Physical, Role–Emotional, or Mental Health domains. Conclusion Treatment with SXB was associated with a dose-dependent improvement in HRQoL, with the 9-g nightly dose demonstrating a positive impact on PCS and individual SF-36 domains of Vitality, GH, and Physical and Social Functioning. | fr |
dcterms.isPartOf | urn:ISSN:2193-8253 | fr |
dcterms.isPartOf | urn:ISSN:2193-6536 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | Bogan, R., Swick, T., Mamelak, M., Kovacevic-Ristanovic, R., Lai, C., Black, J., ... & Montplaisir, J. (2016). Evaluation of quality of life in patients with narcolepsy treated with sodium oxybate: use of the 36-item short-form health survey in a clinical trial. Neurology and therapy, 5(2), 203-213. | fr |
UdeM.VersionRioxx | Version originale de l'auteur·e / Author's Original | fr |
oaire.citationTitle | Neurology and therapy | |
oaire.citationVolume | 5 | |
oaire.citationIssue | 2 | |
oaire.citationStartPage | 203 | |
oaire.citationEndPage | 213 |
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