GBA mutations are associated with Rapid eye movement sleep behavior disorder
Article [Version of Record]
Is part of
Annals of clinical and translational neurology ; vol. 2, no. 9, pp. 941-945.Publisher(s)
WileyAuthor(s)
Abstract(s)
Rapid eye movement sleep behavior disorder and GBA mutations are both
associated with Parkinson’s disease. The GBA gene was sequenced in idiopathic
rapid eye movement sleep behavior disorder patients (n = 265), and compared
to controls (n = 2240). Rapid eye movement sleep behavior disorder questionnaire was performed in an independent Parkinson’s disease cohort (n = 120).
GBA mutations carriers had an OR of 6.24 (10.2% in patients vs. 1.8% in controls, P < 0.0001) for rapid eye movement sleep behavior disorder, and among
Parkinson’s disease patients, the OR for mutation carriers to have probable
rapid eye movement sleep behavior disorder was 3.13 (P = 0.039). These results
demonstrate that rapid eye movement sleep behavior disorder is associated with
GBA mutations, and that combining genetic and prodromal data may assist in
identifying individuals susceptible to Parkinson’s disease.